| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Correlation between Serum Vitamin D Binding Protein and Serum Calcium in Bronchial Asthma and the Effects of Single Nucleotide Polymorphisms |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
asthma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
vitamin D binding protein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
calcium |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
CYP2R1 |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
single nucleotide polymorphisms |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Koyama, Kenya
Koyama, Akemi
Irokawa, Masahiro
Kondo, Chika
Miyo, Kenta
Hasegawa, Tomoki
Ozaki, Atsutaka
Sato, Junya
Kobayashi, Takayuki
Satoh, Hideyuki
Fukushima, Yasutsugu
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 4,
号 2,
p. 124-133,
発行日 2025-04-25
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| 記事種別 |
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|
値 |
Original |
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Bronchial asthma (BA) is characterized by airway stenosis due to chronic airway inflammation. CYP2R1 is an enzyme primarily responsible for vitamin D metabolism, and some of its single nucleotide polymorphisms (SNPs) have been implicated in BA. Vitamin D binding protein (VDBP) is primarily responsible for vitamin D transport, and some of its SNPs have also been implicated in asthma. Here, we investigated the relationship between serum VDBP, serum 25(OH)D, and serum calcium, as well as correlations between serum VDBP and laboratory data, in Japanese patients with BA and healthy donors (HDs). We also compared results between genotypes at SNPs of CYP2R1 (rs12794714 and rs10741657) and an SNP of VDBP (rs7041). Serum VDBP levels were significantly higher in the BA group compared with the HD group. Laboratory data did not differ between SNP genotypes in either group. The only parameter significantly correlated with VDBP was serum calcium in both groups. In addition, serum VDBP was correlated with serum calcium in all genotypes in the HD group, but was correlated with only the AA/AG genotype at rs12794714 and rs10741657 and TT/TG genotype at rs7041 in the BA group. Thus, SNP genotypes with an A allele (AA and AG) at rs12794714 and rs10741657 and a T allele (TT and TG) at rs7041, but not the GG genotype, may be involved in the serum VDBP-mediated regulation of serum calcium in BA. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2024-039 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-2-4.pdf (171 KB)
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