| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
A Case of Liver Injury as an Immune-related Adverse Event in Squamous Cell Carcinoma of the Lung with Successful Life-saving Treatment |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immune-related adverse event |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
irAE |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
immune checkpoint inhibitor |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
liver injury |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Hasegawa, Tomoki
Fukushima, Yasutsugu
Kusama, Haruna
Azuma, Hayase
Ito, Yukari
Takahashi, Tomomi
Ozaki, Atsutaka
Sato, Junya
Tada, Kazuhiro
Kobayashi, Takayuki
Koyama, Kenya
Hirata, Hirokuni
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 4,
号 2,
p. 152-157,
発行日 2025-04-25
|
| 記事種別 |
|
|
値 |
Case Report |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A patient with lung squamous cell carcinoma, cT4N3M1c (OSS), Stage IVB developed Grade 4 hepatic impairment after 2 cycles of carboplatin + paclitaxel + nivolumab + ipilimumab as first-line chemotherapy. Clinically, an immune-related adverse event (irAE) was suspected and pulse therapy with 1 g methylprednisolone for 3 days was administered twice, followed by prednisolone 100 mg/day and mycophenolate mofetil 2000 mg/day, resolving the hepatic impairment. Immune checkpoint inhibitors can cause severe irAEs, as in the present case where cytotoxic chemotherapy combined with anti-PD-1 and anti-CTLA-4 antibodies caused Grade 4 irAE liver injury, which was successfully treated with steroids and immunosuppressants. |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.51040/dkmj.2024-032 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-2-9.pdf (439 KB)
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