| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
Serum Vitamin D Binding Protein in Asthma-Chronic Obstructive Pulmonary Disease Overlap and the Individual Diseases |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
vitamin D binding protein |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
asthma-chronic pulmonary obstructive disease overlap |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
smokingrelated airway constriction |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
eosinophilic chronic pulmonary obstructive disease |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Koyama, Kenya
Koyama, Akemi
Irokawa, Masahiro
Kondo, Chika
Miyo, Kenta
Hasegawa, Tomoki
Ozaki, Atsutaka
Sato, Junya
Tada, Kazuhiro
Kobayashi, Takayuki
Satoh, Hideyuki
Fukushima, Yasutsugu
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 4,
号 3,
p. 197-204,
発行日 2025-06-25
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| 記事種別 |
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|
値 |
Original |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Vitamin D binding protein (VDBP) has been shown to influence asthma and chronic obstructive pulmonary disease (COPD), but its specific effects are unclear. Moreover, serum VDBP has not been investigated in asthma-COPD overlap (ACO). In this study, we compared serum concentrations of VDBP among 252 participants (63 patients with ACO, 70 with bronchial asthma, 69 with COPD, and 50 healthy donors). We also analyzed correlations of blood VDBP concentration with smoking, serum immunoglobin E, peripheral blood eosinophil and neutrophil counts, serum calcium, serum 25-hydroxyvitamin D3, respiratory function (FEV1: forced expiratory volume in 1 s), and fractional exhaled nitric oxide in ACO, bronchial asthma, and COPD. Serum VDBP concentrations were significantly lower in the healthy donors compared with the ACO, bronchial asthma, and COPD groups (all p < 0.05), but did not differ significantly among ACO, bronchial asthma, and COPD. Analysis of correlations of various parameters with serum VDBP concentration showed a negative correlation with smoking history (pack-years) (r = -0.266, p = 0.037) and a positive correlation with FEV1 (r = 0.267, p = 0.036) for ACO, but no correlation between serum VDBP and smoking history or FEV1 for bronchial asthma or COPD. A positive correlation between serum VDBP and peripheral blood eosinophil count was found for COPD alone (r = 0.279, p = 0.039). These results suggest that VDBP influences smoking-related respiratory dysfunction in ACO and peripheral blood eosinophil count in COPD. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
識別子タイプ |
DOI |
|
|
関連識別子 |
https://doi.org/10.51040/dkmj.2024-042 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-3-3.pdf (126 KB)
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