| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
|
|
タイトル |
APC Mutations in Prior Hepatitis B Virus-infected Non-cancerous Tissues and Their Association with Hepatocellular Cancer Recurrence |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
prior hepatitis B infection |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hepatocellular carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
APC |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Wnt/β-catenin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Sato, Shun
Maruyama, Reo
Shimizu, Takayuki
Matsumoto, Takatsugu
Shiraki, Takayuki
Mori, Shozo
Iso, Yukihiro
Shibata, Chikako
Ito, Yuka
Kogai, Takahiko
Ishida, Kazuyuki
Aoki, Taku
|
| 書誌情報 |
en : Dokkyo Medical Journal
巻 4,
号 3,
p. 205-214,
発行日 2025-06-25
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| 記事種別 |
|
|
値 |
Original |
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Backgrounds The molecular mechanisms by which prior hepatitis B virus infection leads to hepatocellular carcinoma are not established. This study aimed to elucidate these mechanisms by investigating the gene mutation profiles associated with the development of hepatocellular carcinoma in patients with prior hepatitis B virus infection. Methods Surgical specimens were resected in our department. We analyzed cancerous and non-cancerous liver tissues from three groups: (1) patients with hepatocellular carcinoma following prior hepatitis B virus infection, (2) patients with hepatocellular carcinoma during active hepatitis B virus infection, and (3) patients with a history of prior hepatitis B virus infection but without hepatocellular carcinoma. DNA extracted from the tissues was screened for mutations potentially associated with carcinogenesis. Results Patients who developed hepatocellular carcinoma after a prior hepatitis B virus infection exhibited mutation profiles similar to those of patients with active hepatitis B virus infection in cancerous and noncancerous areas. This similarity suggests that no unique gene mutations are associated with hepatocellular carcinoma development in the context of prior hepatitis B virus infection. However, patients with APC mutations in non-cancerous liver tissues have a higher likelihood of hepatocellular carcinoma recurrence than those without such mutations. Conclusions Our findings indicated that APC mutations play a significant role in the development of hepatocellular carcinoma in patients with a history of hepatitis B virus infection. Further studies are required to elucidate the role of this gene in hepatitis B virus-associated carcinogenesis. |
|
言語 |
en |
| 出版者 |
|
|
出版者 |
Dokkyo Medical Society |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-522X |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12941861 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
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|
関連識別子 |
https://doi.org/10.51040/dkmj.2024-044 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
DKMJ-4-3-4.pdf (499 KB)
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