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Targeting PHGDH Improves Antitumor Action of LAT1 Inhibitor on Pancreatic Cancer
https://dmu.repo.nii.ac.jp/records/2000706
https://dmu.repo.nii.ac.jp/records/20007067c538866-f204-4a63-8f24-548dd12e91fa
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DKMJ-4-3-6.pdf (163 KB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||
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| タイトル | ||||||||||
| タイトル | Targeting PHGDH Improves Antitumor Action of LAT1 Inhibitor on Pancreatic Cancer | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | L-type amino acid transporter 1 | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | phosphoglycerate dehydrogenase | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | amino acid starvation response | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | pancreatic cancer | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
Hayashi, Keitaro
× Hayashi, Keitaro
× Fujita, Tomoe
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| 書誌情報 |
en : Dokkyo Medical Journal 巻 4, 号 3, p. 223-227, 発行日 2025-06-25 |
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| 記事種別 | ||||||||||
| 値 | Original | |||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | L-type amino acid transporter 1 (LAT1) is predominantly expressed in a wide variety of cancer cells and plays a pivotal role in providing the amino acids required for cancer growth. LAT1 inhibition has attracted considerable attention as a novel strategy for cancer therapy. However, cancer cells can cope with nutrient deprivation, which reduces the efficacy of LAT1 inhibitor. Herein, we report that phosphoglycerate dehydrogenase (PHGDH) diminishes the antitumor effects of LAT1 inhibition. LAT1 inhibitor upregulated PHGDH in MIA PaCa-2 human pancreatic cancer cells. Furthermore, the antitumor effects of LAT1 inhibitor on MIA PaCa-2 were enhanced when combined with PHGDH inhibitor. Our results suggest novel strategy to improve the efficacy of LAT1 inhibitor in cancer therapy by targeting the nutrient starvation response. | |||||||||
| 言語 | en | |||||||||
| 出版者 | ||||||||||
| 出版者 | Dokkyo Medical Society | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | EISSN | |||||||||
| 収録物識別子 | 2436-522X | |||||||||
| 書誌レコードID | ||||||||||
| 収録物識別子タイプ | NCID | |||||||||
| 収録物識別子 | AA12941861 | |||||||||
| DOI | ||||||||||
| 関連タイプ | isIdenticalTo | |||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2024-051 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
