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Combining the FIB-4 Index with the aMAP Score to Enhance Prediction of Liver Carcinogenesis in HCV-SVR Patients
https://dmu.repo.nii.ac.jp/records/2000716
https://dmu.repo.nii.ac.jp/records/2000716ada85554-b2eb-4d4f-a5c7-6d4affd7b0c6
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DKMJ-4-4-3.pdf (368 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| タイトル | ||||||||||||||||||||||
| タイトル | Combining the FIB-4 Index with the aMAP Score to Enhance Prediction of Liver Carcinogenesis in HCV-SVR Patients | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Hepatitis C | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Hepatocellular carcinoma | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Age-male-albumin-bilirubin-platelets score | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | Fibrosis-4 index | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 著者 |
Masaoka, Rion
× Masaoka, Rion
× Shirahashi, Ryosaku
× Kusano, Yumi
× Soma, Yuki
× Sakakibara, Kazuma
× Yamada, Sotarou
× Soga, Koichi
× Tamano, Masaya
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| 書誌情報 |
en : Dokkyo Medical Journal 巻 4, 号 4, p. 290-299, 発行日 2025-08-25 |
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| 記事種別 | ||||||||||||||||||||||
| 値 | Original | |||||||||||||||||||||
| 内容記述 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | Background and aim: The background of liver carcinogenesis has shifted from viral hepatitis to sustained virological response (SVR) of hepatitis C virus (HCV) due to the advent of direct-acting antiviral agents (DAAs). The aMAP score is useful for predicting liver carcinogenesis in HCV-SVR patients, but limitations remain, particularly in medium- and high-risk groups. This study aimed to identify the best factor to combine with the aMAP score to improve predictive accuracy. Methods: We reviewed 286 patients who achieved HCV-SVR. Patients were divided into two groups based on cancer development. Clinical characteristics at 12 weeks post-SVR were compared using the paired Wilcoxon test, and the cut-off values for liver carcinogenesis were determined using the receiver-operating characteristic (ROC) curve. Patients were classified by the aMAP scores as follows: less than 50 for low-risk, 50 to 59 for medium-risk, more than 60 for high-risk for liver carcinogenesis. Results: After excluding 30 patients due to insufficient follow-up, 256 patients were analyzed. During the observation period, 13 patients (5.1%) developed hepatocellular carcinoma (HCC). Alanine aminotransferase (ALT), α-fetoprotein, platelet count, shear wave velocity, and the FIB-4 index were identified as promising factors for combination with the aMAP score. The combination of the FIB-4 index (cut-off value 2.57) with the aMAP score was optimal for predicting liver carcinogenesis, increasing the HCC occurrence rate in medium-and high-risk groups compared to that in high-risk group of the aMAP score alone (13.6%, 12/88 vs. 9.2%, 11/119). Conclusions: The FIB-4 index is the best factor to combine with the aMAP score for predicting liver carcinogenesis after HCV-SVR, especially in medium- and high-risk groups (aMAP score more than 50). |
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| 言語 | en | |||||||||||||||||||||
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| 出版者 | Dokkyo Medical Society | |||||||||||||||||||||
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 2436-522X | |||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA12941861 | |||||||||||||||||||||
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| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2024-045 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
