{"created":"2025-11-19T06:47:15.954606+00:00","id":2000716,"links":{},"metadata":{"_buckets":{"deposit":"37d5f794-5705-4df1-b508-c75a576a1fee"},"_deposit":{"created_by":14,"id":"2000716","owner":"14","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2000716"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:02000716","sets":["223:1763515339399"]},"author_link":[],"control_number":"2000716","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"299","bibliographicPageStart":"290","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Dokkyo Medical Journal","bibliographic_titleLang":"en"}]}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Background and aim: \nThe background of liver carcinogenesis has shifted from viral hepatitis to sustained virological response (SVR) of hepatitis C virus (HCV) due to the advent of direct-acting antiviral agents (DAAs). The aMAP score is useful for predicting liver carcinogenesis in HCV-SVR patients, but limitations remain, particularly in medium- and high-risk groups. This study aimed to identify the best factor to combine with the aMAP score to improve predictive accuracy.\n\nMethods: \nWe reviewed 286 patients who achieved HCV-SVR. Patients were divided into two groups based on cancer development. Clinical characteristics at 12 weeks post-SVR were compared using the paired Wilcoxon test, and the cut-off values for liver carcinogenesis were determined using the receiver-operating characteristic (ROC) curve. Patients were classified by the aMAP scores as follows: less than 50 for low-risk, 50 to 59 for medium-risk, more than 60 for high-risk for liver carcinogenesis.\n\nResults: \nAfter excluding 30 patients due to insufficient follow-up, 256 patients were analyzed. During the observation period, 13 patients (5.1%) developed hepatocellular carcinoma (HCC). Alanine aminotransferase (ALT), α-fetoprotein, platelet count, shear wave velocity, and the FIB-4 index were identified as promising factors for combination with the aMAP score. The combination of the FIB-4 index (cut-off value 2.57) with the aMAP score was optimal for predicting liver carcinogenesis, increasing the HCC occurrence rate in medium-and high-risk groups compared to that in high-risk group of the aMAP score alone (13.6%, 12/88 vs. 9.2%, 11/119).\n\nConclusions: \nThe FIB-4 index is the best factor to combine with the aMAP score for predicting liver carcinogenesis after HCV-SVR, especially in medium- and high-risk groups (aMAP score more than 50).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dokkyo Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.51040/dkmj.2024-045","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12941861","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-522X","subitem_source_identifier_type":"EISSN"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Masaoka, Rion","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shirahashi, Ryosaku","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kusano, Yumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Soma, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sakakibara, Kazuma","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yamada, Sotarou","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Soga, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tamano, Masaya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-11-19"}],"filename":"DKMJ-4-4-3.pdf","filesize":[{"value":"368 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"url":"https://dmu.repo.nii.ac.jp/record/2000716/files/DKMJ-4-4-3.pdf"},"version_id":"cafb72aa-299a-4e21-b391-9d8a5ced3cb2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hepatitis C","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hepatocellular carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Age-male-albumin-bilirubin-platelets score","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis-4 index","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combining the FIB-4 Index with the aMAP Score to Enhance Prediction of Liver Carcinogenesis in HCV-SVR Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combining the FIB-4 Index with the aMAP Score to Enhance Prediction of Liver Carcinogenesis in HCV-SVR Patients","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"14","path":["1763515339399"],"publish_date":"2025-11-19","publish_status":"0","recid":"2000716","relation_version_is_last":true,"title":["Combining the FIB-4 Index with the aMAP Score to Enhance Prediction of Liver Carcinogenesis in HCV-SVR Patients"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2025-11-26T05:28:28.057868+00:00"}