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Histological Characterization of Epithelial Cell Populations in Respiratory Epithelial Adenomatoid Hamartoma
https://dmu.repo.nii.ac.jp/records/2000777
https://dmu.repo.nii.ac.jp/records/20007775f56e13f-1687-4bd2-909a-cc9ddf2db3e1
| 名前 / ファイル | ライセンス | アクション |
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DKMJ-4-5-3.pdf (2 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| タイトル | ||||||||||||
| タイトル | Histological Characterization of Epithelial Cell Populations in Respiratory Epithelial Adenomatoid Hamartoma | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | airway | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | ciliated cells | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | secretory cells | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | goblet cells | |||||||||||
| キーワード | ||||||||||||
| 言語 | en | |||||||||||
| 主題Scheme | Other | |||||||||||
| 主題 | basal cells | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 著者 |
Nakayama, Tsuguhisa
× Nakayama, Tsuguhisa
× Tsunemi, Yasuhiro
× Kashiwagi, Takashi
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| 書誌情報 |
en : Dokkyo Medical Journal 巻 4, 号 5, p. 370-377, 発行日 2025-10-25 |
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| 記事種別 | ||||||||||||
| 値 | Original | |||||||||||
| 内容記述 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Backgrounds: Clinically, respiratory epithelial adenomatoid hamartoma (REAH) is often indistinguishable from nasal polyps on endoscopic examination. However, its clinical management differs substantially, as REAH typically requires complete surgical excision. Despite increasing recognition of the lesion, its pathogenesis and underlying cellular composition remain poorly understood. Objectives: To characterize and compare the distribution of major epithelial cell types―basal, secretory, and ciliated cells―in the surface and submucosal regions of REAH, chronic rhinosinusitis with nasal polyps (CRSwNP), and control sinonasal tissues. Methods: Formalin-fixed, paraffin-embedded tissue specimens were collected from healthy controls (uncinate process), CRSwNP patients (nasal polyps), and REAH patients (olfactory cleft masses). Immunofluorescence staining was performed using markers for basal cells (Cytokeratin 5 (CK5)), differentiated cells (Cytokeratin8 (CK8)), secretory/goblet cells (Mucin 5AC (MUC5AC)), and ciliated cells (acetylated α-tubulin (α-tubulin)). Results: No significant differences were observed in the architecture of the surface epithelium among the groups. However, the submucosal regions demonstrated distinct profiles: CRSwNP lacked epithelial elements; control tissues showed CK8-positive, MUC5AC-negative secretory glands without basal or ciliated cells; and REAH tissues exhibited submucosal glands containing CK5-positive basal cells, CK8- and MUC5AC-positive secretory/goblet cells, and α-tubulin -positive ciliated cells. This composition closely resembled surface respiratory epithelium. Conclusions: REAH demonstrates a unique submucosal epithelial profile, characterized by the coexistence of basal, secretory/goblet, and ciliated cells, in contrast to control and CRSwNP tissues. These findings support the classification of REAH as a hamartomatous lesion and highlight the diagnostic value of identifying these specific epithelial cell subtypes. |
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| 言語 | en | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | Dokkyo Medical Society | |||||||||||
| ISSN | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 2436-522X | |||||||||||
| 書誌レコードID | ||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||
| 収録物識別子 | AA12941861 | |||||||||||
| DOI | ||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | https://doi.org/10.51040/dkmj.2025-014 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
