{"created":"2023-06-20T14:26:35.891168+00:00","id":2188,"links":{},"metadata":{"_buckets":{"deposit":"52444db1-bb27-4e26-ace9-287a36606c7c"},"_deposit":{"created_by":14,"id":"2188","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2188"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00002188","sets":["81:179"]},"author_link":["10252","1591","6571","6919","5124"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"62","bibliographicPageStart":"55","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Dokkyo Journal of Medical Sciences"}]}]},"item_10001_description_35":{"attribute_name":"要旨(英)","attribute_value_mlt":[{"subitem_description":"Background and Aim：The purpose of this study was to observe the changes over time in liver stiffness measured by shear wave elastography（SWE）in hepatitis C patients during direct-acting antiviral agent（DAA）treatment and evaluate the factors affecting the liver stiffness.\nMethods：The subjects were 206 consecutive patients diagnosed with hepatitis C in the Dokkyo Medical University Saitama Medical Center treated with DAAs. SWE was performed to measure the propagation velocity of shear waves（Vs）before starting treatment（baseline）, at the end of treatment（EOT）, and 12 weeks after EOT（follow-up 12）. The change in Vs（ΔVs）was calculated for the difference between baseline and follow-up 12. Clinical parameters were obtained on the same day as SWE. Multiple regression analysis was used to identify factors related to ΔVs.\nResults：Data from 149 patients were used；all 149 patients achieved sustained virological response. Mean Vs decreased significantly, from 1.58±0.92 m/s at baseline to 1.46±0.27 m/s at EOT（P＝0.00045）. Mean Vs at follow-up 12 was 1.42±0.28 m/s, significantly lower than at EOT（P＝0.00002）. The mean ΔVs was 0.147±0.164 m/s. On multiple regression analysis, prothrombin time％（PT％）and the change in alanine aminotransferase（ΔALT）from baseline were significantly related to ΔVs. Baseline ALT and the FIB4-index tended to affect ΔVs.\nConclusions：In hepatitis C patients, Vs measured by SWE improved with 12 weeks of DAA therapy\nand continued to improve to follow-up 12. Baseline PT％ and ΔALT contributed significantly to the\nimprovement of Vs during DAA treatment, and the FIB-4 index also had a great effect.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"獨協医学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Gastroenterology, Dokkyo Medical University Saitama Medical Center, 2-1-50 Minami-Koshigaya, Koshigaya-shi, Saitama 343-8555, Japan"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shirahashi, Ryosaku","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshikuni","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okawa, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokutomi, Naohiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamano, Masaya","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-09-30"}],"displaytype":"detail","filename":"DJMS-46-2-4.pdf","filesize":[{"value":"180.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DJMS-46-2-Shirahashi-本文","url":"https://dmu.repo.nii.ac.jp/record/2188/files/DJMS-46-2-4.pdf"},"version_id":"6100ad51-539b-4800-b919-ad0234d8bc34"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"direct-acting antiviral agents","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatitis C","subitem_subject_scheme":"Other"},{"subitem_subject":"liver stiffness","subitem_subject_scheme":"Other"},{"subitem_subject":"shear wave elastography","subitem_subject_scheme":"Other"},{"subitem_subject":"sustained virological response","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Factors Related to Liver Stiffness in Patients with Hepatitis C During Direct-acting Antiviral Agent Treatment","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Factors Related to Liver Stiffness in Patients with Hepatitis C During Direct-acting Antiviral Agent Treatment"}]},"item_type_id":"10001","owner":"14","path":["179"],"publish_date":"2019-10-07","publish_status":"0","recid":"2188","relation_version_is_last":true,"title":["Factors Related to Liver Stiffness in Patients with Hepatitis C During Direct-acting Antiviral Agent Treatment"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T15:32:06.426855+00:00"}