@article{oai:dmu.repo.nii.ac.jp:00002314,
 author = {Uematsu, Mayu and Nagase, Akihiko and Onoda, Shou and Tojo, Akihiro and Ishimitsu, Toshihiko},
 issue = {2},
 journal = {Dokkyo Journal of Medical Sciences},
 month = {Jul},
 note = {Chronic kidney disease（CKD）patients, especially the patients with end-stage renal disease（ESRD）who are on dialysis therapy are at high risk for developing cardiovascular diseases, based on the progression of arteriosclerosis which often limit the prognosis of these patients. Arteriosclerosis is initiated by endothelial dysfunction followed by thickening and stiffening of medial layer of arterial wall. In the present study, reactive hyperemia index（RHI）, an index of endothelial function, and augmentation index（AI）, an index of arterial stiffness, were measured in patients on continuous ambulatory peritoneal dialysis（CAPD）, and factors related to these parameters of arteriosclerosis were analyzed. RHI was positively corelated with blood urea nitrogen（BUN）and adiponectin and negatively correlated with serum potassium（K）and C-reactive protein（CRP）. On the other hand, AI was positively correlated with age, systolic blood pressure（BP）and serum potassium. In subsequent multiple regression analyses, BUN, serum K and CRP showed independent correlation with RHI, and systolic BP was the parameter independently correlated with AI. It is suggested that the inflammatory mechanism is involved in the development of endothelial dysfunction in CAPD patients and adequate protein intake may be protective against this. As for the arterial stiffness, long-term
duration of systolic BP is supposed to contribute to the stiffening of arterial wall. In addition, exposure to hyperkalemia may facilitate the development of arteriosclerosis in the CAPD patients. These factors related to the indices of arteriosclerosis are assumed as candidates for the target of intervention attempting to prevent the progression of arteriosclerosis and the incidence of cardiovascular diseases thereby improving the long-term prognosis of ESRD patients on CAPD.},
 pages = {55--66},
 title = {Factors Relating to Vascular Damage in Patients on Continuous Ambulatory Peritoneal Dialysis},
 volume = {47},
 year = {2020}
}