{"created":"2023-06-20T14:25:10.166434+00:00","id":234,"links":{},"metadata":{"_buckets":{"deposit":"1413be32-4223-4ef1-ba12-953c1b4dd385"},"_deposit":{"created_by":3,"id":"234","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"234"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000234","sets":["81:30"]},"author_link":["813","812"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"126","bibliographicPageStart":"117","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"糖尿病症例の創傷治癒遅延は,臨床的にしばしば経験される.しかし,創傷治癒遅延の原因について検討した報告は少ない.本研究では,糖尿病モデルラットを使用し,筋損傷治癒過程における血管新生に関連する成長因子であるvascular endothelial growth factor (VEGF), vascular endothelial growth factor receotor 1 (Fit-1), vascular endothelial growth factor receotor 2(Flk-1), basic fibroblast srowth factor (bFGF), insulin like growth factor-1 (IGF-1), transforming growth factor-beta (TGF-β), nerve growth factor (NGF)のmRNAの発現量を経時的にreal time RT-PCR法を用いて解析し,糖尿病における創傷治癒遅延の原因を検討した.糖尿病ラットでは,成長因子VEGF, bFGF, TGF-beta, NGFの産生分泌過剰を生じていること,およびVEGFのレセプターの1つであるFltの発現異常を認めた.本研究から糖尿病群では,新生血管に対する成長因子のmRNAの過剰発現が存在するにもかかわらず,創傷治癒が良好ではないことが判明した.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Injury to muscles and skin is very common. We have experienced that it is difficult to cure muscle injury and gangrene with Diabetes Mellitus on clinical. It is reported that vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor 1 (Fit-1), vascular endothelial growth factor receptor 2 (Flk-1), basic fibroblast growth factor (bFGF), insulin like growth factor-1 (IGF-1), transforming growth factor-bate (TGF-β), nerve growth factor (NGF) are potent stimulators of angiogenesis in vivo. We therefore analyzed dynamic state of these growth factor in tissue of rats with lacerations of the gastrocenmius muscle by real time RT-PCR method. Our findings showed that quantities of mRNA of VEGF, bFGF, TGF-beta, IGF-1, NGF in muscle regeneration of diabetic rats are more than control muscle. Quantity of mRNA of Fit in deabetic muscle compared abnormally with control muscle. Our results suggest that these growth factors and Fit appeared abnormally in diabetic muscle healing and may have a considerable effect on the treatment of diabetic muscle.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学整形外科学"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Dokkyo University School of Medicine Department of Orthopedics"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"トウニョウビョウ ラット キン ソンショウ チユ カテイ ニオケル セイチョウ インシ mRNA ノ カジョウ ハツゲン"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今村, 直樹"},{"creatorName":"イマムラ, ナオキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imamura, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00004091327.pdf","filesize":[{"value":"927.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004091327.pdf","url":"https://dmu.repo.nii.ac.jp/record/234/files/KJ00004091327.pdf"},"version_id":"c5f97d80-5217-419d-a30b-fc63ce2bc7c8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病"},{"subitem_subject":"筋損傷"},{"subitem_subject":"血管新生"},{"subitem_subject":"成長因子"},{"subitem_subject":"Diabetes Mellitus","subitem_subject_language":"en"},{"subitem_subject":"muscle injury","subitem_subject_language":"en"},{"subitem_subject":"angiogenesis","subitem_subject_language":"en"},{"subitem_subject":"growth factor","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"糖尿病ラット筋損傷治癒過程における成長因子mRNAの過剰発現","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病ラット筋損傷治癒過程における成長因子mRNAの過剰発現"},{"subitem_title":"Role of Growth Factors in Angiogenesis of Muscle Healing with Diabetic Rat","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["30"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"234","relation_version_is_last":true,"title":["糖尿病ラット筋損傷治癒過程における成長因子mRNAの過剰発現"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:25:27.329850+00:00"}