@article{oai:dmu.repo.nii.ac.jp:00002420,
 author = {Akutsu, Makoto and Kanaya, Hiroaki and Kashiwagi, Takashi and Tsunemi, Yasuhiro and Haruna, Shin-ichi},
 issue = {3},
 journal = {Dokkyo Journal of Medical Sciences},
 month = {Oct},
 note = {Background：Eosinophilic chronic rhinosinusitis（ECRS） is an intractable subtype of chronic rhinosinusitis（CRS）, which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive （MMP-8＋）neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS.
Methods：Nasal polyps （NPs）in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8＋ neutrophils in NPs were evaluated in combination with histological and clinical parameters.
Results：MMP-8＋ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8＋ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group；however, the percentage of MMP-8＋ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8＋ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8＋ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group.
Conclusions：This study suggests that MMP-8＋ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8＋neutrophils might become a candidate of nasal therapeutic target for patients with ECRS.},
 pages = {125--136},
 title = {Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study},
 volume = {47},
 year = {2020}
}