{"created":"2023-06-20T14:26:45.658118+00:00","id":2420,"links":{},"metadata":{"_buckets":{"deposit":"b3c05e28-9849-4b81-ae9b-9da446b7d8ba"},"_deposit":{"created_by":14,"id":"2420","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"2420"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00002420","sets":["81:189"]},"author_link":["10821","1619","10820","10819","10818"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"136","bibliographicPageStart":"125","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Dokkyo Journal of Medical Sciences"}]}]},"item_10001_description_35":{"attribute_name":"要旨(英)","attribute_value_mlt":[{"subitem_description":"Background：Eosinophilic chronic rhinosinusitis（ECRS） is an intractable subtype of chronic rhinosinusitis（CRS）, which is characterized by marked polyp formation. This study is intended to understand the involvement of matrix metalloproteinase-8-positive （MMP-8＋）neutrophils in the disease progression of ECRS by comparing it to that of non-ECRS.\nMethods：Nasal polyps （NPs）in patients with ECRS and non-ECRS were investigated using immunofluorescence staining, and the ratios of MMP-8＋ neutrophils in NPs were evaluated in combination with histological and clinical parameters.\nResults：MMP-8＋ neutrophils in NP were clearly identified in immunofluorescence staining. The percentage of MMP-8＋ neutrophils in NPs was significantly increased in the ECRS group compared to that in the non-ECRS group. The ECRS group presented higher tissue remodeling scores than the non-ECRS group；however, the percentage of MMP-8＋ neutrophils was not correlated with the severity of tissue remodeling. Furthermore, the percentage of MMP-8＋ neutrophils was mildly inverse correlated with the remodeling scores in ECRS patients. Although the ECRS group presented higher values than the non- ECRS group with respect to computed tomography scores, endoscopic polyp scores, olfaction recognition thresholds, and the percentage of MMP-8＋ neutrophils showed a statistically significant correlation only among the subgroups defined by computed tomography scores in the ECRS group.\nConclusions：This study suggests that MMP-8＋ neutrophils may participate in the progression of ECRS, particularly by initiating NP formation in the paranasal sinus mucosa at the early stages of ECRS. MMP-8＋neutrophils might become a candidate of nasal therapeutic target for patients with ECRS.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"獨協医学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_25":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Otorhinolaryngology-Head and Neck Surgery, Dokkyo Medical University"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akutsu, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanaya, Hiroaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1619","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kashiwagi, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsunemi, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haruna, Shin-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"10821","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-06"}],"displaytype":"detail","filename":"DJMS-47-3-3.pdf","filesize":[{"value":"337.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DJMS-47-3-Akutsu-本文","url":"https://dmu.repo.nii.ac.jp/record/2420/files/DJMS-47-3-3.pdf"},"version_id":"dc7c04ae-abe5-424b-a4dc-681511f6a0e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tissue remodeling","subitem_subject_scheme":"Other"},{"subitem_subject":"Histopathology","subitem_subject_scheme":"Other"},{"subitem_subject":"Computed tomography score","subitem_subject_scheme":"Other"},{"subitem_subject":"Polyp score","subitem_subject_scheme":"Other"},{"subitem_subject":"Olfaction recognition threshold","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study"}]},"item_type_id":"10001","owner":"14","path":["189"],"publish_date":"2021-01-06","publish_status":"0","recid":"2420","relation_version_is_last":true,"title":["Matrix Metalloproteinase-8-positive Neutrophils in Nasal Polyps Are Involved in the Disease Progression of Eosinophilic Chronic Rhinosinusitis ：a Clinico-pathological Study"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T15:12:13.127483+00:00"}