{"created":"2023-06-20T14:25:12.772033+00:00","id":295,"links":{},"metadata":{"_buckets":{"deposit":"a91ab239-aca6-4b33-8798-672085be4b78"},"_deposit":{"created_by":3,"id":"295","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"295"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000295","sets":["81:31"]},"author_link":["1197","1191","1196","1199","1193","1201","1190","1198","1192","1194","1195","1200"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"233","bibliographicPageStart":"225","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"当院臨床検査部では,依頼された検査が診療に役立つように精度管理を徹底し,検査方法の改善や測定の迅速化などを検討している.今回,心筋トロポニンIとT(cTnIとcTnT),ミオグロビン(Mb),CK-MB蛋白(CK-MB mass),CK-MB活性測定(CK-MB),心房ナトリウム利尿ペプチド(ANP),脳性ナトリウム利尿ペプチド(BNP)の検査方法,精度,特性について急性及び慢性心疾患患者の依頼検体265試料を用いて検討した.その結果,cTnIはcTnTと良好な相関関係を示し,測定値はcTnTに比べ約8倍の高値を認めた.急性心筋梗塞(AMI)患者検体のcTnI,Mb,CK-MB massおよびCK-MBは良好な変動を示した.cTnTはcTnIに比べると上昇率が小さく変動も少なかったが,Cut off値と比較するとほぼ同様な変化を認めた.AMI以外の慢性心疾患でもcTnI,CK-MB mass,ANP,BNPは基準値を超える測定値を示した.今回の結果から,心疾患の潜在的な進行や悪化が疑われた場合はcTnIとBNPの測定が他の心筋マーカーと同様に有意義であり,今後も検査部では優れた測定精度と迅速な検査法の検討を続ける必要があることが示唆された.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Our goals are to maintain the accuracy of various medical tests, to improve test methods, and to reduce the measurement time. In this study we examined the method, accuracy and time required for measurement of cardiac troponins (cTnT and cTnI), myoglobin (Mb), CK- MB protein mass (CK-MB mass), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) using 265 samples of patients with acute and chronic heart disease. The coefficient of variation (C.V%) was measured of cTnI (1.9%, 2.2%), cTnT (2.4%, 2.5%), Mb (1.2%, 1.7%), CK-MBmass (1.6%, 2.6%), ANP (5.6%, 7.6%) and BNP (7.1%, 9.4%), and CK-MB (2.1%). cTnI had a good correlation with cTnT (r=0.845, P<0.001 ; n=120) and showed approximately 8-fold high concentrations compared with cTnT. In patients with acute myocardial infarction (AMI), changes in cTnI, Mb and CK-MB mass showed good sensitivity in the early stage, whereas cTnT showed little change. cTnI, CK-MB mass, ANP and BNP were also mostly positive in patients with chronic heart disease, excluding AMI. The results of this study considered that measurement of cardiac markers is useful in patients with heart disease. The sensitivity, accuracy and measurement time for such assays should be further improved, and the utility of the assay items should be evaluated.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学病院臨床検査部"},{"subitem_text_value":"獨協医科大学病院臨床検査部:獨協医科大学臨床検査医学"},{"subitem_text_value":"獨協医科大学病院臨床検査部"},{"subitem_text_value":"獨協医科大学病院臨床検査部"},{"subitem_text_value":"獨協医科大学病院臨床検査部:獨協医科大学臨床検査医学"},{"subitem_text_value":"獨協医科大学内科学(心血管・肺)"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Laboratory, Dokkyo University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Laboratory, Dokkyo University Hospital:Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Laboratory, Dokkyo University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Laboratory, Dokkyo University Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Clinical Laboratory, Dokkyo University Hospital:Department of Clinical Laboratory Medicine, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Cardiology and Neurology Medicine, Dokkyo University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ケッセイ シンキン マーカー ソクテイ セイド ト ユウヨウセイ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"堀内, 裕次"},{"creatorName":"ホリウチ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松田, 隆子"},{"creatorName":"マツダ, リュウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中尾, 美佐子"},{"creatorName":"ナカオ, ミサコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"及川, 信次"},{"creatorName":"オイカワ, シンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"家入, 蒼生夫"},{"creatorName":"イエイリ, タミオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金子, 昇"},{"creatorName":"カネコ, ノボル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Horiuchi, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuda, Ryuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakao, Misako","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oikawa, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ieiri, Tamio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kaneko, Noboru","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00004161778.pdf","filesize":[{"value":"767.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004161778.pdf","url":"https://dmu.repo.nii.ac.jp/record/295/files/KJ00004161778.pdf"},"version_id":"b871e56f-a021-44e7-bdae-ebd7051cbb84"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血清心筋マーカー"},{"subitem_subject":"精度"},{"subitem_subject":"感度"},{"subitem_subject":"急性心筋梗塞"},{"subitem_subject":"慢性心疾患"},{"subitem_subject":"serum cardiac marker","subitem_subject_language":"en"},{"subitem_subject":"accuracy","subitem_subject_language":"en"},{"subitem_subject":"sensitivity","subitem_subject_language":"en"},{"subitem_subject":"acute myocardial infarction","subitem_subject_language":"en"},{"subitem_subject":"Chronic heart disease","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"血清心筋マーカー測定精度と有用性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血清心筋マーカー測定精度と有用性"},{"subitem_title":"Evaluation of the Accuracy and Usefulness of Serum Cardiac Marker Assays","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["31"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"295","relation_version_is_last":true,"title":["血清心筋マーカー測定精度と有用性"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:27:04.304850+00:00"}