{"created":"2023-06-20T14:25:13.801824+00:00","id":319,"links":{},"metadata":{"_buckets":{"deposit":"512c5d11-102b-4dd1-8bfa-077eefdefa0a"},"_deposit":{"created_by":3,"id":"319","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"319"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000319","sets":["81:33"]},"author_link":["1250","1249"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"20","bibliographicPageStart":"13","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"急性心筋梗塞の治療では早期に梗塞責任病変を再灌流させることが,短期及び長期予後に非常に有益である.本研究は急性心筋梗塞における冠血管形成術前の血栓溶解剤であるモンテプラーゼの先行投与の有用性を評価するための単一施設での前向き無作為試験である.対象は1998年1月から2003年12月までに入院した連続372例の急性心筋梗塞のうち,発症12時間以内,75歳以下の140例であり,モンテプラーゼ先行投与(27,500 IU/kg)後に冠血管形成術を行った群(M群n=65)と冠血管形成術単独群(P群n=75)に無作為に割り付けた.第一のエンドポイントは2年間の臨床的追跡調査である.入院中の出血性合併症(脳出血,消化管出血,輸血を必要とした出血)はM群で1例にのみ見られた.死亡率は両群間で有意差を認めなかった(M群3.1% vs P群5.3%,NS).心血管イベントの発生率はM群で有意に低率であった(M群27.7% vs P群46.7%,P=0.02).近年の血栓溶解剤の進歩を考慮すると,血栓溶解剤併用の有益性について再評価すべきであると考える.モンテプラーゼ先行投与と冠血管形成術の併用は有効な急性心筋梗塞の治療戦略の一つである.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The patency of the infarct-related artery, which is achieved mainly with thrombolysis or percutaneous coronary intervention (PCI), has strong beneficial influence on short-and long-term outcome in patients with acute myocardial infarction (AMI). The combining monteplase with angioplasty (COMA) trial is a prospective randomized, and single-center trial for evaluating the effectiveness of monteplase administration prior to emergent PCI in AMI. Out of 372 consecutive acute myocardial infarction from January 1988 to December 2003, we enrolled into the COMA trial 140 patients who were under 75 years of age and had been admitted within 12 hours after the onset of AMI. Patients were randomly assigned to receive direct PCI (group P, n=65) or PCI followed by pretreatment with intravenous monteplase (group M, n=75). The primary endpoint was clinical outcome during 2 years of follow-up. In-hospital, major bleeding including cerebral hemorrhage and gastrointestinal bleeding or other bleeding requiring blood transfusion, were observed in no patients in Group P and in one patient in group M. Mortality was no significant difference between two groups (group M 3.1% vs group 5.3 % NS). However, total incidence rate of the major adverse clinical event (MACE) with group M were lower than group P (27.7 % vs 46.7 %, P=0.004). Considering the development of the modern thrombolytic agent as well as the progression of PCI procedure itself, we should now re-evaluate the theoretical advantage of combining the administration of thrombolysis agents. We recommend a combination therapy of PCI with monteplase injection as a sound strategy for AMI.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院循環器内科"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"キュウセイ シンキン コウソク ニ タイスル カンケッカン ケイセイ ジュツ ニオケル モンテプラーゼ センコウ トウヨ ノ チョウキ セイセキ "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"千田, 龍二"},{"creatorName":"チダ, リュウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chida, Ryuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00004161885.pdf","filesize":[{"value":"679.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004161885.pdf","url":"https://dmu.repo.nii.ac.jp/record/319/files/KJ00004161885.pdf"},"version_id":"1666fcc8-f481-490a-af19-b17f01d731b2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"急性心筋梗塞"},{"subitem_subject":"血栓溶解療法"},{"subitem_subject":"モンテプラーゼ"},{"subitem_subject":"冠血管形成術"},{"subitem_subject":"長期予後"},{"subitem_subject":"心血管イベント"},{"subitem_subject":"acute myocardial infarction (AMI)","subitem_subject_language":"en"},{"subitem_subject":"thrombolytic therapy","subitem_subject_language":"en"},{"subitem_subject":"monteplase","subitem_subject_language":"en"},{"subitem_subject":"perctaneous coronary intervention (PCI)","subitem_subject_language":"en"},{"subitem_subject":"long term outcome","subitem_subject_language":"en"},{"subitem_subject":"major adverse clinical event (MACE)","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"急性心筋梗塞に対する冠血管形成術におけるモンテプラーゼ先行投与の長期成績","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"急性心筋梗塞に対する冠血管形成術におけるモンテプラーゼ先行投与の長期成績"},{"subitem_title":"Long Term Outcome of Monteplase prior to Percutaneous Coronary Intervention for Acute Myocardial Infarction","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["33"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"319","relation_version_is_last":true,"title":["急性心筋梗塞に対する冠血管形成術におけるモンテプラーゼ先行投与の長期成績"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:27:41.681357+00:00"}