{"created":"2023-06-20T14:25:14.676342+00:00","id":339,"links":{},"metadata":{"_buckets":{"deposit":"4932eeff-c753-4196-8f51-9ca433401947"},"_deposit":{"created_by":3,"id":"339","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"339"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000339","sets":["81:34"]},"author_link":["1323","1328","1324","1326","1325","1327","1322"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"89","bibliographicPageStart":"85","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Oxidant stress-induced activation of poly (ADP-ribose) polymerase (PARP) contributes to the pathogenesis of various cardiovascular diseases. Adiponectin is an adipocyte-derived anti-atherogenic protein. In the present study, we investigated the role of PARP in the development of hypoadiponectinemia caused by chronic blockade of nitric oxide synthesis with N^ω-nitro-L-arginine methyl ester (L-NAME) in rats. Decreased production of NO and increased production of O_2^- were observed in aortas from L-NAME-treated rats. Plasma adiponectin levels and adiponectin mRNA levels within adipose tissue were markedly decreased in L-NAME-treated rats. Concurrent administration of potent PARP inhibitors, INO-1001 or PJ34, with L-NAME did not restore plasma adiponectin levels or fat adiponectin mRNA levels. Thus, the cardiovascular protective effects of PARP inhibitors are not associated with adiponectin levels. Therefore, drugs which increase adiponectin levels may be beneficial alongside PARP inhibitors in the treatment of cardiovascular disease.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology & Metabolism, Dokkyo University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Xi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Hiroko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kase, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kunihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwata, Chigusa","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hattori, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kasai, Kikuo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00004439018.pdf","filesize":[{"value":"498.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004439018.pdf","url":"https://dmu.repo.nii.ac.jp/record/339/files/KJ00004439018.pdf"},"version_id":"75534029-d185-4ace-8012-95e73ea8e015"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adiponectin","subitem_subject_language":"en"},{"subitem_subject":"poly (ADP-ribose) polymerase","subitem_subject_language":"en"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en"},{"subitem_subject":"adipocytokine","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["34"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"339","relation_version_is_last":true,"title":["Effect of Poly (ADP-ribose) Polymerase Inhibitors on Hypoadiponectinemia Caused by Chronic Blockade of Nitric Oxide Synthesis in Rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:28:23.797890+00:00"}