@article{oai:dmu.repo.nii.ac.jp:00000392,
 author = {小林, 和弘 and 奥山, 隆 and Kobayashi, Kazuhiro and Okuyama, Takashi},
 issue = {3},
 journal = {Dokkyo journal of medical sciences},
 month = {Oct},
 note = {進行結腸癌におけるc-MET発現と癌浸潤先進部buddingとの関連について検討した.また,c-MET発現とbuddingの治癒切除後の予後因子としての有用性について比較検討した.【対象・方法】治癒切除された進行結腸癌88症例を対象に,HE染色とc-MET免疫組織化学染色を施行した.【成績】c-MET発現はbudding,リンパ節転移,術後再発を認めた症例で有意に多く認められた(p<0.0001, p=0.0013, p=0.0019).予後に関しては累積生存曲線,5年生存率においてc-MET発現とbuddingのそれぞれで,その有無による有意差を認めた(p=0.0028, p=0.0136).さらに,c-MET発現およびbuddingを含めた臨床病理学的所見を予後因子の候補として術後生存期間に関する多変量解析を行うとc-MET発現のみが独立した有意な予後因子であった.【結論】本検討より進行結腸癌におけるbudding形成にHGF/c-MET signalの関与が示唆された.また,治癒切除後の進行結腸癌症例においてc-MET発現は有用な予後因子であった., Introduction Hepatocyte growth factor receptor (c-met) is suggested to play an important role in the progression and metastasis of colorectal cancer. In this study, we investigated the relationship between the expression of c-met and budding in pT3 colon adenocarcinoma. Patients and Methods Curatively resected specimens of 88 pT3 well or moderately differentiated colon adenocarcinoma were studied. The median postoperative follow-up was 70.2 months. We made serial sections from formalin-fixed and paraffin embedded blocks, and performed H-E staining and immunohistochemical staining for c-met. We classified the expression of c-met were evaluated as positive (+) or negative (-). The finding of budding at the invasive front of tumor was recorded according to Morodomi's criteria. Results The expression of c-met was 37 lesions and was significantly correlated with lymphatic invasion, lymphnode metastasis, budding, and overall recurrence (p=0.0006, p<0.0001, p=0.0013, and p=0.0019, respectively). Postoperative survival was significantly shorter in patients with c-MET-positive lesions than in patients with c-MET-negative lesions (p=0.0028, logrank test). Similarly, budding was a significantly prognostic factor (p=0.0136, logrank test). Multivariate proportional hazard model revealed that the expression of c-met was the only significant co-factor of postoperative survival in pT3 colon adenocarcinoma. Conclusion HGF/c-MET signal may affect the formation of budding at the invasive front of tumor. Moreover, c-MET is an useful marker suggesting poor survival in patients with pT3 colon carcinoma., 原著, Original},
 pages = {135--141},
 title = {進行結腸癌におけるc-MET発現とbuddingの関係について},
 volume = {32},
 year = {2005},
 yomi = {コバヤシ, カズヒロ and オクヤマ, タカシ}
}