| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
CD4^+ -Central Memory and Effector Memory T Cells in Patients with Asthma |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
bronchial asthma |
| キーワード |
|
|
言語 |
en |
|
主題 |
CCR4 |
| キーワード |
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|
言語 |
en |
|
主題 |
CCR7 |
| キーワード |
|
|
言語 |
en |
|
主題 |
central memory T cells (TCMs) |
| キーワード |
|
|
言語 |
en |
|
主題 |
effector memory T cells (TEMs) |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
CD4^+ -Central Memory and Effector Memory T Cells in Patients with Asthma |
| 著者 |
Yamaguchi, Bunpei
Hirata, Hirokuni
Honda, Kyoko
Yukawa, Tatsuo
Arima, Masafumi
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| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine |
| 著者所属(英) |
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|
en |
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Department of Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine:Department of Developmental Genetics, Chiba University Graduate School of Medicine |
| 記事種別(日) |
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内容記述タイプ |
Other |
|
内容記述 |
原著 |
| 記事種別(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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|
内容記述タイプ |
Other |
|
内容記述 |
Asthma is associated with chronic airway inflammation, suggesting that its pathogenesis is driven by type 2 helper T (Th2) cells among memory/effector CD4^+ T, cells. CCR4, a chemokine receptor, is considered a preferential marker for Th2 cells. Another chemokine receptor, CCR7, is regarded to be a suitable molecule for T-cell homing to lymph nodes. Recent studies have demonstrated that memory T cells are subdivided into central memory T cells (TCMs) and effector memory T cell (TEMs), designated as CCR7^+ CD62L^+ CD45RA^- and CCR7^- CD62L^- CD45RA^-, respectively. Nevertheless, the properties of TCMs and TEMs in allergic diseases remains unknown. This study focused on the cytokine production and the populations and survival of CD4^+ TCMs and CD4^+ TEMs in patients with asthma (n=3-5), as compared with those in healthy controls (n=4-5). We found that the population of TEMs in asthma was greater than that in healthy control. IL-4-producing cells among both activated TCMs and TEMs and IFN-γ-producing cells among TEMs were more abundant in asthma than in healthy control. Apoptotic cells stained with annexin V and propidium iodide (PI) were more numerous among both TCMs and TEMs in asthma than in healthy control after stimulation with both phorbol myristate acetate and ionomycin. Although CCR4^+ cell populations among TCMs and TEMs were similar in patients with asthma and healthy controls, cytokine-production profiles differed significantly. Namely, CCR4^+ (but not CCR4^-) TCMs and TEMs produced IL-4 and CCR4^+(but not CCR4^-) TCMs produced IFN-γ in both asthma and healthy control. In contrast, both CCR4^+ and CCR4^- TEMs produced IFN-γ. The production levels of IL-4 and IFN-γ by each subpopulation were greater in asthma than in healthy control. Our results suggest that increased CCR4^+-TEMs in peripheral blood accumulate in the lung and to play an important role in the development and maintenance of airway inflammation in asthma. To our knowledge, this is the first study to investigate CCR4^+ TCMs and TEMs in bronchial asthma and healthy controls. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 33,
号 1,
p. 1-10,
発行日 2006-03-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00004451266.pdf (1.0 MB)
