@article{oai:dmu.repo.nii.ac.jp:00000422,
 author = {Masuda, Hiroyuki and Manaka, Takako and Toda, Masao and Sugiyama, Kumiya and Sagara, Hironori},
 issue = {1},
 journal = {Dokkyo journal of medical sciences},
 month = {Mar},
 note = {Mast cells play important roles in both acute-and late-phase allergic reactions mediated by IgE, such as those in bronchial asthma. Remodeling of the airway wall may contribute to the development of chronic refractory asthma; effective treatment for remodeling is currently lacking. Tryptase released by degranulated mast cells may participate in airway remodeling by stimulating the proliferation of airway smooth-muscle cells and fibroblasts and promoting the production of extracellular matrix. We found that continued antigen challenge produced time-dependent increases in the number of goblet cells, which are essential for sputum production, as well as the number of mast cells. Furthermore, the expression of amphiregulin released from mast cells was up-regulated by after ovalbumin challenges in mice. The number of amphiregulin-positive cells positively correlated with the degree of goblet-cell hyperplasia. Our results suggest that mast cells also play a key role in airway remodeling., 原著, Original},
 pages = {43--53},
 title = {Antigen Challenge-induced Expression of Amphiregulin by Mast Cells Increases Goblet-Cell Hyperplasia in a Mouse Model of Asthma},
 volume = {33},
 year = {2006}
}