{"created":"2023-06-20T14:25:18.786591+00:00","id":424,"links":{},"metadata":{"_buckets":{"deposit":"ee2f1017-5674-4077-8453-ea17a09b1c92"},"_deposit":{"created_by":3,"id":"424","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"424"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000424","sets":["81:37"]},"author_link":["1712","1711"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"69","bibliographicPageStart":"61","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"術後痛における神経成長因子(NGF)とロイコトリエンB4(LTB4)の役割を調べるために,Brennanの術後痛ラットモデルを用いて,足底部の皮膚切開部位にNGF,LTB4,抗NGF抗体,LTB4受容体括抗薬であるONO4057を投与して,その疼痛閾値に対する効果をvon Frey testで検討した.結果はNGFとLTB4投与で術後痛は変化しなかったが,抗NGF抗体とONO4057投与により術後痛は有意に減少した.よって抗NGF抗体とONO4057は,術後痛を抑制する可能性が示唆された.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"To examine the role of nerve growth factor (NGF) and leukotoriene B4 (LTB4) in postoperative pain, we examined whether a Peripherally administered NGF, LTB4, anti-NGF and anti-LTB4 would be the effect for incision-induced mechanical hyperalgesia. We used a rat model of postoperative pain introduced by Brennan et al. Rats underwent a plantar incision, and responses to mechanical stimuli was measured using von Frey filaments. Rats were tested 1 and 96 H after the skin incision. Anti-NGF and anti-LTB4 significantly decreased the response frequencies to mechanical stimulation, however, NGF and LTB4 did not evoke mechanical hyperalgesia. We conclude that anti-NGF and anti-LTB4 can inhibit the mechanical hyperalgesia induced by a surgical incision.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院 麻酔科"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Anesthesiology, Koshigaya hospital, Dokkyo University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"ジュツゴツウ ラット モデル ニオケル シンケイ セイチョウ インシ ト ロイコトリエンB4 ノ サヨウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久野, 裕一郎"},{"creatorName":"クノ, ユウイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kuno, Yuichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00004451273.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004451273.pdf","url":"https://dmu.repo.nii.ac.jp/record/424/files/KJ00004451273.pdf"},"version_id":"97b8f7b3-ad48-41f8-953b-0c876b02ee33"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経成長因子"},{"subitem_subject":"ロイコトリエンB4"},{"subitem_subject":"術後痛"},{"subitem_subject":"Nerve growth factor (NGF)","subitem_subject_language":"en"},{"subitem_subject":"LeukotorieneB4 (LTB4)","subitem_subject_language":"en"},{"subitem_subject":"Postoperative pain","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用"},{"subitem_title":"The Effect of Nerve Growth Factor and LeukotorienB4 in a Rat Model of Postoperative Pain","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["37"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"424","relation_version_is_last":true,"title":["術後痛ラットモデルにおける神経成長因子とロイコトリエンB4の作用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:20:21.810749+00:00"}