{"created":"2023-06-20T14:25:19.006445+00:00","id":428,"links":{},"metadata":{"_buckets":{"deposit":"5e77bae5-8a0a-4742-98dc-4c4f4a253bdb"},"_deposit":{"created_by":3,"id":"428","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"428"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000428","sets":["81:37"]},"author_link":["1738","1737","1739","1727","1740","1728","1736","1733","1741","1742","1734","1731","1735","1732","1730","1729"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"104","bibliographicPageStart":"95","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"気管支喘息は気道への好酸球を中心とする慢性アレルギー性炎症性疾患として認識され,その患者は各種IgE抗体を発現し,対応するアレルゲン暴露により気道にIgEを介するアレルギー性炎症が惹起される.一方,CD40LigandはTリンパ球,肥満細胞などに発現し,CD40との伝達を介してBリンパ球のIgE産生細胞への分化,増殖に働いており,IgE産生において重要な働きをしている.しかし好酸球におけるCD40Ligand発現とIgE産生へ役割は明確ではない.我々は気管支喘息患者末梢血好酸球のCD40Ligand発現とそれがBリンパ球IgE産生誘導に与える影響について検討した.(方法)気管支喘息患者末梢血より好酸球を分離精製し,各種サイトカインで刺激しCD40L発現を検討した.また精製Bリンパ球と混合培養し上清中のIgEを測定した,(結果)気管支喘息患者群の末梢血好酸球は健常者群に比較し優位にCD40Ligandを発現し,またBリンパ球は好酸球との混合培養によりIL-4,IL-13存在下にIgEを産生した.(考案)気管支喘息患者好酸球はTリンパ球とは別個に独立してBリンパ球のIgE産生に関与する可能性が示唆された.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Bronchial asthma is a chronic inflammatory disease of the airway.The accumulation of eosinophils in the airway is one of characteristic seen in patients with bronchial asthma. Asthmatic patients have a large number of IgE antibodies to environmental allergens. The exposure of these allergens induces IgE mediated allergic inflammation in the airway. Allergic reaction is a most important aspect of airway inflammation of the bronchial asthma. It is well known that CD40/CD40-Ligand interaction is a key factor for IgE production. CD40-Ligand, a surface molecule which can be expressed by T cells, mast cells and basophils has been shown to be involved in the control of B cell proliferation. We have observed following in vitro study. It have been shown that freshly isolated eosinophils from asthmatic subjects can be induced to express CD40-Ligand but not from normal controls. IgE synthesis can be induced by the interaction of B cells with eosinophils in the presence of exogenous IL-13. These result suggest that eosinophils can induce the production of IgE, independently of T cells.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー):上武呼吸器科内科病院"},{"subitem_text_value":"獨協医科大学 内科学(呼吸器・アレルギー)"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine:Jobu Hospital for Respiratory Disease"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary medicine and Clinical Immunology, Dokkyo University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"IgE サンセイ ニ アタエル コウサンキュウ ジョウ リガンド ノ ヤクワリ "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 壮令"},{"creatorName":"オカダ, タケノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相良, 博典"},{"creatorName":"サガラ, ヒロノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 真弓"},{"creatorName":"オオタ, マユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"増田, 浩之"},{"creatorName":"マスダ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"眞塩, 一樹"},{"creatorName":"マシオ, カズキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笛木, 真"},{"creatorName":"フエキ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笛木, 直人"},{"creatorName":"フエキ, ナオト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"福田, 健"},{"creatorName":"フクダ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Takenori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sagara, Hironori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuda, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mashio, Kazuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fueki, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fueki, Naoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00004451277.pdf","filesize":[{"value":"743.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004451277.pdf","url":"https://dmu.repo.nii.ac.jp/record/428/files/KJ00004451277.pdf"},"version_id":"d12cc37f-d6d1-4a47-981f-2992df68bea4"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"検索用語"},{"subitem_subject":"ヒト好酸球"},{"subitem_subject":"気管支喘息"},{"subitem_subject":"CD40リガンド(CD154)"},{"subitem_subject":"IgE"},{"subitem_subject":"Human eosinophil","subitem_subject_language":"en"},{"subitem_subject":"Bronchial asthma","subitem_subject_language":"en"},{"subitem_subject":"CD40ligand (CD154)","subitem_subject_language":"en"},{"subitem_subject":"IgE","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"IgE産生に与える好酸球上CD40リガンドの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"IgE産生に与える好酸球上CD40リガンドの役割"},{"subitem_title":"The Role of CD40Ligand Expression on Eosinophil for IgE Production","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["37"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"428","relation_version_is_last":true,"title":["IgE産生に与える好酸球上CD40リガンドの役割"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:20:26.755532+00:00"}