{"created":"2023-06-20T14:29:03.571437+00:00","id":5061,"links":{},"metadata":{"_buckets":{"deposit":"996809f8-3f45-4d34-a7ad-beeff315718a"},"_deposit":{"created_by":14,"id":"5061","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"5061"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00005061","sets":["81:220"]},"author_link":["46550","46549","6909"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"86","bibliographicPageStart":"81","bibliographicVolumeNumber":"48","bibliographic_titles":[{"bibliographic_title":"Dokkyo Journal of Medical Sciences"}]}]},"item_10001_description_34":{"attribute_name":"要旨","attribute_value_mlt":[{"subitem_description":"Purpose：The effect of 5-HT2B receptor-selective agonist BW723C86 was investigated on the outflow of 5-hydroxytryptamine（5-HT）from isolated muscle layer-free mucosal preparations of guinea-pig colon.\nMethods：The mucosal preparations were incubated in vitro and the outflow of 5-HT from these preparations was determined by high-performance liquid chromatography with electrochemical detection.\nResults：BW723C86（1-10 μM）produced a sustained increase in the outflow of 5-HT from the mucosal preparations. The BW723C86-evoked 5-HT outflow was inhibited by the two different 5-HT2B receptor antagonists, olanzapine（100 nM）and RS127445（100 nM）. The neuropeptide Y1 receptor antagonist BIBO3304（300 nM）markedly inhibited the BW723C86-evoked 5-HT outflow.\nConclusion：We found that 5-HT2B receptor-triggered 5-HT release from guinea-pig colonic mucosa is mediated by the activation of 5-HT2B receptors located at endocrine cells and that the 5-HT2B receptortriggered 5-HT release is mediated by endogenously released peptide YY, acting via Y1 receptors. Given that both 5-HT and peptide YY are well-known mediators of nausea and vomiting, the 5-HT2B receptors located at endocrine cells may play a role in the generation of nausea and vomiting.","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"獨協医学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan"},{"subitem_text_value":"Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan"},{"subitem_text_value":"Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, Tochigi 321-0293, Japan"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kojima, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kojima, Shu-ichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Tomoe","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-09-24"}],"displaytype":"detail","filename":"DJMS-48-2-5.pdf","filesize":[{"value":"242.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DJMS-48-2-Kojima-本文","url":"https://dmu.repo.nii.ac.jp/record/5061/files/DJMS-48-2-5.pdf"},"version_id":"6114f4c2-8eab-4397-bcb6-f336f831b7c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BW723C86","subitem_subject_scheme":"Other"},{"subitem_subject":"guinea-pig colon","subitem_subject_scheme":"Other"},{"subitem_subject":"5-HT2B receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"5-HT release","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropeptide Y1 receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"peptide YY","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa：a Role of Endogenous Peptide YY","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa：a Role of Endogenous Peptide YY"}]},"item_type_id":"10001","owner":"14","path":["220"],"publish_date":"2021-09-24","publish_status":"0","recid":"5061","relation_version_is_last":true,"title":["5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa：a Role of Endogenous Peptide YY"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T14:52:28.208181+00:00"}