{"created":"2023-06-20T14:29:06.884630+00:00","id":5119,"links":{},"metadata":{"_buckets":{"deposit":"2eab6e45-36db-426e-b013-0849bb3f25e2"},"_deposit":{"created_by":14,"id":"5119","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"5119"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00005119","sets":["223:225"]},"author_link":["11750","46323","9833","46671","68","46329","5832","46667","46331","46668","40","46669","46666","46673","46674","46672","46670"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"62","bibliographicPageStart":"56","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Dokkyo Medical Journal"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Introduction: Comprehensive genomic profiling (CGP) was widely adopted in Japan after its coverage by national healthcare insurance began in June 2019. We investigated the clinical utility of CGP in pediatric and adolescent young adults (AYA) solid tumor patients.\n　Materials and Methods: Between November 2017 and December 2019, 13 patients who progressed with or who were likely to progress with standard therapies were recruited to the PROFILE-F study to undergo CGP using either FoundationOneⓇ CDx or FoundationOneⓇ Heme.\n　Results: The median age was 28 years old. Tumor types were as follows: neuroblastoma (n = 1), Wilms’ tumor (n = 1), rhabdomyosarcoma (n = 2), Ewing sarcoma (n = 1), gastric cancer (n = 1), rectal cancer (n = 1), osteosarcoma (n = 1), neuroendocrine tumor (n = 2), salivary gland carcinoma (n = 1), tracheal adenoid cystic carcinoma (n = 1), and thymic cancer (n = 1). In 92% of cases, at least one genomic alteration was identified, including CDKN2A (four cases), TP53 (three cases), and MYC (two cases). Actionable aberrations were found in 10 cases (77%), and a clinical trial candidate was found in seven cases (54%). However, no patients were able to receive biomarker-matched therapy according to their genomic alterations.\n　Conclusions: Further efforts to increase basket trials and collection of clinical genomic data to predict response are necessary to advance precision cancer medicine and surgical management in pediatric and AYA populations.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dokkyo Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.51040/dkmj.1.1_56","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-5211","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Tokyo Medical and Dental University;First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Tokyo Medical and Dental University"},{"subitem_text_value":"Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Tokyo Medical and Dental University"},{"subitem_text_value":"Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Tokyo Medical and Dental University"},{"subitem_text_value":"Department of Specialized Surgeries, Tokyo Medical and Dental University"},{"subitem_text_value":"Department of Specialized Surgeries, Tokyo Medical and Dental University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"First Department of Surgery, Dokkyo Medical University"},{"subitem_text_value":"Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Tokyo Medical and Dental University"},{"subitem_text_value":"Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University"},{"subitem_text_value":"Department of Precision Cancer Medicine, Center for Innovative Cancer Treatment, Tokyo Medical and Dental University;Moores Cancer Center, University of California"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsudera, Shotaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kano, Yoshihito","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoyagi, Yasuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tohyama, Kohki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogino, Kei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okamoto, Kentaro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamaguchi, Takeshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Shun","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakajima, Masanobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morita, Shinji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakamura, Takatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Kan","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchioka, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kojima, Kazuyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miyake, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takagi, Masatoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Sadakazu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"DKMJ-1-1-10.pdf","filesize":[{"value":"423.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"DKMJ-1-1-Matsudera-Fulltext","url":"https://dmu.repo.nii.ac.jp/record/5119/files/DKMJ-1-1-10.pdf"},"version_id":"f3f2f3f8-a3cb-4d7d-9fd4-845816085c46"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-04-20"}],"displaytype":"detail","filename":"DKMJ-1-1-10-S.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"DKMJ-1-1-Matsudera-Supplement","url":"https://dmu.repo.nii.ac.jp/record/5119/files/DKMJ-1-1-10-S.pdf"},"version_id":"fa57570f-085c-4064-af3d-35893b44bb84"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"comprehensive genomic profiling","subitem_subject_scheme":"Other"},{"subitem_subject":"pediatric and AYA solid tumor patients","subitem_subject_scheme":"Other"},{"subitem_subject":"precision cancer medicine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Pilot Study of Comprehensive Genomic Profiling for Pediatric and Adolescent and Young Adult Solid Tumor Patients in Japan","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Pilot Study of Comprehensive Genomic Profiling for Pediatric and Adolescent and Young Adult Solid Tumor Patients in Japan"}]},"item_type_id":"10001","owner":"14","path":["225"],"publish_date":"2022-04-25","publish_status":"0","recid":"5119","relation_version_is_last":true,"title":["A Pilot Study of Comprehensive Genomic Profiling for Pediatric and Adolescent and Young Adult Solid Tumor Patients in Japan"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T14:45:11.277854+00:00"}