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  1. Dokkyo Medical Journal
  2. 1(3) 2022

Physicochemical Properties of α-Taxilin as a Putative Tethering Factor

https://dmu.repo.nii.ac.jp/records/5256
https://dmu.repo.nii.ac.jp/records/5256
d8ee8a96-d01e-453e-8ce0-56cc90d21760
名前 / ファイル ライセンス アクション
DKMJ-1-3-3.pdf DKMJ-1-3-Higashi-Fulltext (546.1 kB)
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Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Physicochemical Properties of α-Taxilin as a Putative Tethering Factor
言語
言語 eng
キーワード
主題Scheme Other
主題 α-taxilin
キーワード
主題Scheme Other
主題 intracellular vesicle traffic
キーワード
主題Scheme Other
主題 SNARE
キーワード
主題Scheme Other
主題 syntaxin
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Higashi, Satoru

× Higashi, Satoru

en Higashi, Satoru

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Shirataki, Hiromichi

× Shirataki, Hiromichi

en Shirataki, Hiromichi

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著者所属
値 Department of Molecular and Cell Biology, Graduate School of Medicine, Dokkyo Medical University, Tochigi, Japan
著者所属
値 Department of Molecular and Cell Biology, Graduate School of Medicine, Dokkyo Medical University, Tochigi, Japan
書誌情報 Dokkyo Medical Journal

巻 1, 号 3, p. 167-175, 発行日 2022-09
抄録
内容記述タイプ Abstract
内容記述 α-Taxilin is a member of the taxilin family, a binding partner of the syntaxin family involved in intracellular vesicle traffic. The taxilin family members share a long coiled-coil structure, which is homologous to that of Uso1, a yeast homologue of p115. It has been revealed that a parallel homodimerization of p115, an elongated polypeptide, is required for tethering of the transport vesicles to the acceptor membrane. In this study we examined whether α-taxilin has similar biochemical properties to p115. Gel filtration and sedimentation analyses suggest that α-taxilin is an elongated polypeptide containing a long coiled-coil structure. A pull-down assay revealed that His6-α-taxilin binds to GST-α-taxilin, and not to GST in dose-dependent and saturable manners. α-Taxilin formed a parallel homodimer through at least two independent regions. Together, α-taxilin may be involved in tethering of the transport vesicles to the acceptor membranes in a similar way to p115.
記事種別
値 Original
出版者
出版者 Dokkyo Medical Society
ISSN
収録物識別子タイプ ISSN
収録物識別子 2436-522X
DOI
識別子タイプ DOI
関連識別子 10.51040/dkmj.2022-002
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