{"created":"2023-06-20T14:25:24.483982+00:00","id":535,"links":{},"metadata":{"_buckets":{"deposit":"a194e55f-bd33-44aa-a688-5be0c2734bf8"},"_deposit":{"created_by":3,"id":"535","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"535"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000535","sets":["81:41"]},"author_link":["2191"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T29","bibliographicPageStart":"T21","bibliographicVolumeNumber":"34","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"t(17;19)急性リンパ性白血病acute lymphoblastic leukemia (t(17;19)^+ ALL)はE2A-HLFの抗アポトーシス能により白血病化する. t(17;19)^+ ALLはsurvivinが高発現し, E2A-HLFドミナントネガティブ変異dominant negative (dn)の導入でsurvivinの発現が抑制される一方, t(17;19)を有しないALL (t(17;19)^- ALL)細胞にE2A-HLFを導入するとsurvivinが高発現した. Survivinはt(17;19)^+ ALLでは全細胞周期で高発現していた.レポーターアッセイでE2A-HLFはsurvivinプロモーターの細胞周期関連領域を制御していた. t(17;19)^+ ALL細胞にsurvivin (dn)を導入すると全細胞周期でアポトーシスが生じた.以上の結果からE2A-HLFが細胞全周期においてsurvivinを発現誘導し白血病化に関与していることが示唆された.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Doctoral Treatise","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学小児科学"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Survivin ワ E2A-HLF ユウゴウ テンシャ インシ ノ カリュウ デ ハッケツビョウ カ ニ カンヨ スル"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥谷, 真由子"},{"creatorName":"オクヤ, マユコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00005058611.pdf","filesize":[{"value":"905.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005058611.pdf","url":"https://dmu.repo.nii.ac.jp/record/535/files/KJ00005058611.pdf"},"version_id":"42d5d2d4-90dc-4e77-a321-cedcc7656d4d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"survivin"},{"subitem_subject":"E2A-HLF"},{"subitem_subject":"t(17;19)^+ ALL"},{"subitem_subject":"アポトーシス"},{"subitem_subject":"細胞周期非依存的発現"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する"}]},"item_type_id":"2","owner":"3","path":["41"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"535","relation_version_is_last":true,"title":["SurvivinはE2A-HLF融合転写因子の下流で白血病化に関与する"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:09:33.484470+00:00"}