{"created":"2023-06-20T14:29:18.592662+00:00","id":5357,"links":{},"metadata":{"_buckets":{"deposit":"809fb262-0af0-4217-9327-337315e4d5a7"},"_deposit":{"created_by":14,"id":"5357","owners":[14],"pid":{"revision_id":0,"type":"depid","value":"5357"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00005357","sets":["223:236"]},"author_link":["47273","47274","3544","3534","3537","438","4223","3540"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"291","bibliographicPageStart":"285","bibliographicVolumeNumber":"1","bibliographic_titles":[{"bibliographic_title":"Dokkyo Medical Journal"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To determine whether tumor necrosis factor (TNF) blockade improves small airway obstruction in rheumatoid arthritis (RA) patients without apparent respiratory symptoms.\n\nMethods: Pulmonary function tests were performed before and one year after TNF blockade therapy in 29 RA patients without apparent respiratory symptoms. As a control, pulmonary function was examined at a one-year interval in 27 RA patients with conventional disease-modifying antirheumatic drugs (DMARDs) alone. Small airway obstruction was diagnosed when one of maximal mid-expiratory flow rate (MMEF), forced expiratory flow at 50% (FEF50) or 75% (FEF75) of the vital capacity was decreased to less than 60%, 55%, or 45% of predicted values, respectively.\n\nResults: Small airway obstruction was found in 62.5% of RA patients. No differences were found in age, sex, disease duration, or disease activities. TNF inhibitors dramatically reduced disease activities. However, TNF inhibitors failed to improve small airway obstructions but worsened them.\n\nConclusions: TNF blockade fails to improve small airway obstruction, suggesting that TNF-independent pathways play important roles in the development of small airway obstruction in RA.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dokkyo Medical Society"}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.51040/dkmj.2022-013","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-522X","subitem_source_identifier_type":"ISSN"}]},"item_10001_text_24":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"},{"subitem_text_value":"Department of Rheumatology, Dokkyo Medical University School of Medicine, Tochigi, Japan"}]},"item_10001_text_33":{"attribute_name":"記事種別","attribute_value_mlt":[{"subitem_text_value":"Original"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamazaki, Ryutaro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47273","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurasawa, Kazuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3544","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagasawa, Junya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"47274","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Ayae","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arai, Satoko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3534","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Owada, Takayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3537","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arima, Masafumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maezawa, Reika","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3540","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-03-27"}],"displaytype":"detail","filename":"DKMJ-1-4-3.pdf","filesize":[{"value":"128.8 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"DKMJ-1-4-Yamazaki-Fulltext","url":"https://dmu.repo.nii.ac.jp/record/5357/files/DKMJ-1-4-3.pdf"},"version_id":"52c90ee1-b233-493c-8502-9fd1f363345a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"rheumatoid arthritis","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF blockade","subitem_subject_scheme":"Other"},{"subitem_subject":"small airway disease","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary function","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis"}]},"item_type_id":"10001","owner":"14","path":["236"],"publish_date":"2023-03-27","publish_status":"0","recid":"5357","relation_version_is_last":true,"title":["Tumor Necrosis Factor Blockade Fails to Improve Small Airway Obstruction in Rheumatoid Arthritis"],"weko_creator_id":"14","weko_shared_id":-1},"updated":"2023-06-20T14:41:35.664706+00:00"}