{"created":"2023-06-20T14:25:29.661871+00:00","id":644,"links":{},"metadata":{"_buckets":{"deposit":"aa288766-2a0a-4e83-a9a8-77a82a9483bc"},"_deposit":{"created_by":3,"id":"644","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"644"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000644","sets":["81:45"]},"author_link":["2645","2644"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"36","bibliographicPageStart":"27","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"近年,強力な骨吸収抑制作用を持つビスフォスフォネート製剤が骨粗鬆症の治療に使用されている.長期間(3年以上,平均±SE:6.0±1.2年)のホルモン補充療法(hormone replacement therapy:HRT)を施行中の骨量減少患者を対象にリセドロネート2.5mg/日を投与し[Risedronate (Ris)+HRT群, n=11],投与前と投与後42ヶ月間, 6ヶ月に1回,骨密度(bone mineral density:BMD)を測定した.また,長期HRT施行中でBMDが正常の比較的高齢女性(HRT単独群,平均59.7±1.6歳, n=13),およびHRTを行っていないがBMDが正常の高齢女性(無治療群,平均57.3±1.6歳, n=20)の42ヶ月にわたるBMDの変化を比較した. Ris+HRT群のBMDは投与開始後全期間を通じて持続的に有意に増加した. HRT単独群のBMDは全期間を通じて有意な変化を認めなかったが,無治療群のBMDは,観察開始後18～42ヶ月で有意に低下した.これらより長期HRT施行中の骨量減少患者に対するリセドロネートのBMD増加効果を明らかにした.また,高齢女性における長期HRT (半量投与を含む)のBMD維持効果が判明した.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Hormone replacement therapy (HRT) improves the bone mineral density (BMD) of postmenopausal patients with osteoporosis or osteopenia. However, treatment with long-term HRT for more than 3 years diminishes an increasing effect on BMD but prevents further bone loss. The present studies were designed to investigate the effects of rise-dronate (Ris), a pyridinyl bisphosphonate, on BMD in osteopenic postmenopausal women with a mean age of 50.3±2.9 years who had received long-term HRT for more than 3 years and of long-term HRT on BMD in relatively older women with normal BMD. 2.5mg daily of risedronate was administered for 42 months to 11 osteopenic postmenopausal women treated with long-term HRT, the duration of which was 6.0±1.2 years (Ris+HRT group). BMD and biochemical bone markers were determined at the initiation of observation and thereafter every 6 months for 42 months in the above-mentioned 11 osteopenic women, 13 relatively older women with a mean age of 59.2±1.6 years who had received long-term HRT for an average of 6.1±0.7 years (HRT group) and other 20 relatively older women with a mean age of 57.3±1.6 years who had never received HRT (non-HRT group), The BMD in the women of both older groups were normal when the study was initiated. Percent changes of BMD in the Ris+HRT group were significantly increased all through the 42 months. Those in the HRT group did not show any significant changes for 42 months and those in the non-HRT group were significantly decreased between 18 and 42 months after the initiation of observation. These results indicate that Ris significantly increases the BMD in those who had received long-term HRT and treatment with long-term HRT including half a dose of HRT is effective for maintaining the BMD in older postmenopausal women.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院産科婦人科"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University Koshigaya Hospital"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"チョウキ ホルモン ホジュウ リョウホウ (hormone replacement therapy:HRT) シコウチュウ ノ コツリョウ ゲンショウ ヘイケイゴ ジョセイ ノ コツミツド ニ タイスル ビスフォスフォネート セイザイ ヘイヨウ コウカ ト チョウキ HRT シコウチュウ ノ コウレイ ジョセイ 二オケル コツミツド ノ ヘンカ ニ カンスル リンショウテキ ケンキュウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱田, 佳伸"},{"creatorName":"ハマダ, ヨシノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamada, Yoshinobu","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00005058748.pdf","filesize":[{"value":"813.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005058748.pdf","url":"https://dmu.repo.nii.ac.jp/record/644/files/KJ00005058748.pdf"},"version_id":"2fbb5dee-eb67-4ebd-8723-e058f2971caa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨量減少"},{"subitem_subject":"ホルモン補充療法"},{"subitem_subject":"リセドロネート"},{"subitem_subject":"ビスフォスフォネート"},{"subitem_subject":"骨代謝マーカー"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"長期ホルモン補充療法(hormone replacement therapy:HRT)施行中の骨量減少閉経後女性の骨密度に対するビスフォスフォネート製剤併用効果と長期HRT施行中の高齢女性における骨密度の変化に関する臨床的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"長期ホルモン補充療法(hormone replacement therapy:HRT)施行中の骨量減少閉経後女性の骨密度に対するビスフォスフォネート製剤併用効果と長期HRT施行中の高齢女性における骨密度の変化に関する臨床的研究"},{"subitem_title":"The Additive Effect of Risedronate, a Bisphosphonate, on the Bone Mineral Density (BMD) in Osteopenic Postmenopausal Women Treated with Long-term Hormone Replacement Therapy (HRT) and the Long-term HRT Effect on the BMD in Older Postmenopausal Women","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["45"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"644","relation_version_is_last":true,"title":["長期ホルモン補充療法(hormone replacement therapy:HRT)施行中の骨量減少閉経後女性の骨密度に対するビスフォスフォネート製剤併用効果と長期HRT施行中の高齢女性における骨密度の変化に関する臨床的研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:12:19.791732+00:00"}