{"created":"2023-06-20T14:25:30.164825+00:00","id":655,"links":{},"metadata":{"_buckets":{"deposit":"d58ac8d3-cb42-4251-b7b2-0c15c6b09b77"},"_deposit":{"created_by":3,"id":"655","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"655"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000655","sets":["81:45"]},"author_link":["2678"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T50","bibliographicPageStart":"T43","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Wistar系雄性ラットを用い,心筋梗塞を作製後,慢性期にフェニレフリンによるα_1受容体刺激をおこない,左室拡張機能ならびにCa^<2+>結合蛋白質アネキシンVの細胞内移動について免疫組織学的に検討した.ラット左冠状動脈前下行枝を結集し, 10-13週間後に,梗塞群(n=6)と非梗塞群(sham-ope群, n=4)にフェニレフリンを30μg/kg/分で, 30分間投与した.心拍数,左室収縮期圧(LVP max),左室拡張最小圧(LVP min),左室拡張末期圧(LVEDP)を測定し,左室圧一次微分の最大陽性dP/dt (+dP/dt),左室圧一次微分の最大陰性dP/dt (-dP/dt)を計測した.梗塞群ではフェニレフリン投与後,左室拡張最小庄(p<0.05),左室拡張末期圧(p<0.05)が有意に上昇し,左室拡張障害を惹起した.非梗塞群ではフェニレフリン投与で拡張障害は起こらなかった.梗塞群で梗塞サイズと左室拡張最小圧(p<0.01),左室拡張末期圧(p<0.01), -dP/dt (p<0.001)は有意な正の相関関係を示した.更に,梗塞心の非梗塞部心筋ではフェニレフリン投与によりアネキシンVの細胞質からの消失,細胞外逸脱を認めた.以上より,慢性梗塞心においてはα_1受容体刺激により容易に拡張障害を起こすこと,その際,アネキシンVの細胞内移動を伴うことが明らかとなった.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(心血管・肺)"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"α_1 ジュヨウタイ シゲキ ニヨル サシツ カクチョウ ショウガイ ノ ハッセイ ニ カンスル ケントウ : ラット コウソクシン ニヨル ジッケンテキ ケントウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西, 悠"},{"creatorName":"ニシ, ユウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00005058759.pdf","filesize":[{"value":"940.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005058759.pdf","url":"https://dmu.repo.nii.ac.jp/record/655/files/KJ00005058759.pdf"},"version_id":"cf9642bc-eb32-41f4-8fdd-55484311975f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"心筋梗塞"},{"subitem_subject":"左室拡張障害"},{"subitem_subject":"フェニレフリン"},{"subitem_subject":"α_1受容体刺激"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"α_1受容体刺激による左室拡張障害の発生に関する検討 : ラット梗塞心による実験的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"α_1受容体刺激による左室拡張障害の発生に関する検討 : ラット梗塞心による実験的検討"}]},"item_type_id":"2","owner":"3","path":["45"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"655","relation_version_is_last":true,"title":["α_1受容体刺激による左室拡張障害の発生に関する検討 : ラット梗塞心による実験的検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:12:39.181410+00:00"}