{"created":"2023-06-20T14:25:30.482061+00:00","id":662,"links":{},"metadata":{"_buckets":{"deposit":"5fe1507a-80d1-40ef-aaee-3b5b639d64ac"},"_deposit":{"created_by":3,"id":"662","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"662"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000662","sets":["81:45"]},"author_link":["2685"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T112","bibliographicPageStart":"T99","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"関節リウマチ(Rheumatoid arthritis, RA)発症においてTumor Necrosis Factor (TNF)など炎症性サイトカインは重要な役割を果たしている.また, T細胞も重要な役割を果たしているが,その異常は不明な点がある.近年導入されたTNF阻害療法はRAの炎症,関節破壊を劇的に抑制し,一部の症例には治癒状態を誘導する.しかし, TNF阻害療法のT細胞異常に与える効果は不明である.本研究は末梢T細胞分化に着目し, RA患者にT細胞分化異常が存在するか, TNF阻害療法がそれを是正するか明らかにすることを目標とする.そのためにTNF阻害療法および疾患修飾性抗リウマチ剤(Disease modifying anti-rheumatic drugs, DMARDs)投与患者の末梢T細胞分化表面マーカーを経時的に解析した. RA患者においてはT細胞分化異常があり, terminally differentiated effector memory T細胞(CD4陽性CD28^<null> T細胞およびCD8陽性CD45RA memory effector細胞)が増大していた. T細胞分化異常は, TNF阻害療法により,疾患活動性のコントロールともに是正されるが, DMARDsでは是正されなかった.したがって, TNF阻害療法にはT細胞への作用という新たな効果が存在することおよびその作用がRA治癒誘導において働く可能性が示唆された.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Tumor necrosis factor ソガイ リョウホウ ワ カンセツ リウマチ カンジャ ノ マッショウ Tサイボウ ブンカ イジョウ (terminal differentiated effector memory Tサイボウ ノ ゾウダイ) オ ゼセイ スル"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大原, 徹也"},{"creatorName":"オオハラ, テツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00005058766.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005058766.pdf","url":"https://dmu.repo.nii.ac.jp/record/662/files/KJ00005058766.pdf"},"version_id":"d9b4181d-32b3-4b33-a117-3fce6fd1f849"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tumor necrosis factor阻害療法"},{"subitem_subject":"関節リウマチ"},{"subitem_subject":"T細胞分化異常"},{"subitem_subject":"DMARDs"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Tumor necrosis factor阻害療法は関節リウマチ患者の末梢T細胞分化異常(terminal differentiated effector memory T細胞の増大)を是正する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Tumor necrosis factor阻害療法は関節リウマチ患者の末梢T細胞分化異常(terminal differentiated effector memory T細胞の増大)を是正する"}]},"item_type_id":"2","owner":"3","path":["45"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"662","relation_version_is_last":true,"title":["Tumor necrosis factor阻害療法は関節リウマチ患者の末梢T細胞分化異常(terminal differentiated effector memory T細胞の増大)を是正する"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:12:48.469657+00:00"}