{"created":"2023-06-20T14:25:31.157284+00:00","id":677,"links":{},"metadata":{"_buckets":{"deposit":"a84f5e49-6447-46ce-a8dc-4433826a1b9d"},"_deposit":{"created_by":3,"id":"677","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"677"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000677","sets":["81:46"]},"author_link":["2722","2731","2737","2733","2724","2721","2727","2726","2736","2725","2729","2732","2735","2738","2723","2734","2728","2730"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"92","bibliographicPageStart":"85","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"気管支喘息の基本的病態は慢性の気道炎症として認識され,その機序が徐々に解明されてきている.特に重症・難治化には気道リモデリングがその要因として注目されている.今回,我々は神経原性炎症に深く関与している神経ペプチド(サブスタンスP,ニューロキニンA)が気道リモデリング,特に線維化サイトカインTGF-βのシグナル伝達機構に関与するTIEG, smad 7遺伝子発現に与える影響について検討した.これら神経ペプチドは線維化サイトカインTGF-βの発現を誘導し,さらにTGF-βの抑制型シグナル伝達分子smad 7の遺伝子発現を低下させた.これらの結果より神経ペプチドはTGF-βのシグナル伝達分子smad 7発現を抑制することによりリモデリング形成に関与している可能性が示唆された.持続するTh2型気道炎症はTGF-β産生増加へ傾きTIEG発現を誘導し,その結果smad 7の発現を抑制する事が知られている.我々は,気道平滑筋におけるサブスタンスP刺激によりTIEG遺伝子発現が誘導される事を見出した.また, TGF-β前処置後サブスタンスPで刺激することによりその効果は増強される事も確認した.これらの結果より,アレルギー性炎症により惹起された神経原性炎症はTIEG発現を誘導し,結果としてsmad 7発現が抑制され気道の線維化・リモデリング形成を促進している可能性が示唆された.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Airway remodeling is a typical issue of asthma. Transforming growth factor (TGF)-β plays an important role for the regulation of airway inflammation and remodeling in asthma. The expression of TGF-β in the asthmatic airways was predominantly detected in eosinophils and fibroblasts and it was significantly correlated with the severity of the disease, basement membrane thickness, and submucosal fibroblast number, thus suggesting that TGF-β is involved in airway remodeling in adult asthma. TGF-β-inducible early gene (TIEG) is a Kruppel-like transcription factor that is rapidly induced upon TGF-β treatment TIEG promotes TGF-β/smad signaling by down-regulating negative feedback through the inhibitory smad 7. Among numerous peptide mediators such as tachykinin, calcitonin gene-related peptide, substance P or neurokinin A is one of the most abundant molecules found in the respiratory tract. Neurogenic inflammation might contribute to selective upregulation of TIEG through unknown mechanisms. We therefore examine whether neuropeptides modulate TGF-β and TIEG expression. In this study, we found that TIEG was significantly increased in the cultured smooth muscle cells stimulating with substance P. Furthermore, we found the synergistic effect on TIEG expression in cultured smooth muscle cells stimulating with substance P and pretreatment of TGF-β. These results suggest that increased TIEG expression in airway epithelial and smooth muscle cells might result in increased substance P, TGF-β activity and contribute to the development of airway inflammation seen in chronic asthma.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー):上武呼吸器科内科病院"},{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー):上武呼吸器科内科病院"},{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"},{"subitem_text_value":"獨協医科大学内科学(呼吸器・アレルギー)"},{"subitem_text_value":"上武呼吸器科内科病院"},{"subitem_text_value":"獨協医科大学医学給合研究所"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine:Jobu Hospital for Respiratory disease"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine:Jobu Hospital for Respiratory disease"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Jobu Hospital for Respiratory disease"},{"subitem_text_language":"en","subitem_text_value":"Institute for Medical Science, Dokkyo Medical University School of Medicine"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"バイヨウ キドウ ジョウヒ サイボウ オヨビ ヘイカツキン サイボウ ニオケル キドウ リモデリング カンレン サイトカイン イデンシ ハツゲン ニ オヨボス シンケイ ペプチド ノ エイキョウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"笛木, 真"},{"creatorName":"フエキ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"橋井, 敦子"},{"creatorName":"ハシイ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"笛木, 直人"},{"creatorName":"フエキ, ナオト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"太田, 真弓"},{"creatorName":"オオタ, マユミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田, 壮令"},{"creatorName":"オカダ, タケノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉山, 公美弥"},{"creatorName":"スギヤマ, クミヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"相良, 博典"},{"creatorName":"サガラ, ヒロノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"牧野, 荘平"},{"creatorName":"マキノ, ソウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"秋元, 一三"},{"creatorName":"アキモト, カズミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fueki, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hashii, Atsuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fueki, Naoto","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ota, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okada, Takenori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sugiyama, Kumiya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sagara, Hironori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Makino, Sohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Akimoto, Kazumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00005058781.pdf","filesize":[{"value":"684.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005058781.pdf","url":"https://dmu.repo.nii.ac.jp/record/677/files/KJ00005058781.pdf"},"version_id":"a1af187a-e375-4360-bc27-67861558cdf8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"気管支喘息"},{"subitem_subject":"TGF-βシグナル"},{"subitem_subject":"smad 7"},{"subitem_subject":"TIEG"},{"subitem_subject":"サブスタンスP"},{"subitem_subject":"Bronchial asthma","subitem_subject_language":"en"},{"subitem_subject":"TGF-β signaling","subitem_subject_language":"en"},{"subitem_subject":"smad 7","subitem_subject_language":"en"},{"subitem_subject":"TIEG","subitem_subject_language":"en"},{"subitem_subject":"substance P","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"培養気道上皮細胞および平滑筋細胞における気道リモデリング関連サイトカイン遺伝子発現におよぼす神経ペプチドの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"培養気道上皮細胞および平滑筋細胞における気道リモデリング関連サイトカイン遺伝子発現におよぼす神経ペプチドの影響"},{"subitem_title":"Effect of Neuropeptides for Cytokine Gene Expression Associated with Airway Remodeling in Cultured Airway Epithelial and Smooth Muscle Cell Lines","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["46"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"677","relation_version_is_last":true,"title":["培養気道上皮細胞および平滑筋細胞における気道リモデリング関連サイトカイン遺伝子発現におよぼす神経ペプチドの影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:13:16.705806+00:00"}