{"created":"2023-06-20T14:25:35.512787+00:00","id":764,"links":{},"metadata":{"_buckets":{"deposit":"4cfc6aff-dee4-48f3-a5f0-df53f17cfdcb"},"_deposit":{"created_by":3,"id":"764","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"764"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000764","sets":["81:49"]},"author_link":["3188"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T53","bibliographicPageStart":"T45","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"陳旧性心筋梗塞ラットで,ノルエピネフリン誘発性拡張障害を惹起させ,その発生様式ならびにリアノジン受容体安定化作用を有する1,4-ベンゾチアゼピン誘導体K201の改善作用を調べた.冠動脈結紮10〜13週間後,ノルエピネフリン(20 mg/kg/分)を30分間投与し,K201 投与群(n=5),非投与群(n=5),sham群(n=3)で,心拍数,左室収縮期圧,左室拡張期最小圧,左室拡張末期圧,+dP/dt,-dP/dtを測定した.K201(0.1 mg/kg/分)はノルエピネフリン投与中に10分間投与した.ノルエピネフリン投与により梗塞サイズと左室拡張期最小圧,左室拡張末期圧との間に正相関があり,K201は心拍数,左室収縮期圧,左室拡張期最小圧,左室拡張末期圧を有意に減少させ,非投与群との%変化率でも拡張能を有意に改善させた.以上よりK201は梗塞心におけるノルエピネフリン誘発拡張障害を改善させ,その作用機序としてK201のa 1受容体遮断作用に加えて,リアノジン受容体安定化作用による細胞内Ca2+負荷の改善が示唆された.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(心血管・肺)"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"サシツ カクチョウ ショウガイ ノ ハッセイ ト ソノ ヨボウ ニ カンスル ジッケンテキ ケントウ : ラット チンキュウセイ コウソクシン ニ ヨル ケントウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西野, 節"},{"creatorName":"ニシノ, セツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006358559.pdf","filesize":[{"value":"379.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006358559.pdf","url":"https://dmu.repo.nii.ac.jp/record/764/files/KJ00006358559.pdf"},"version_id":"e38d9869-04bf-4762-a3f1-4ab1219ed789"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ラット陳旧性心筋梗塞"},{"subitem_subject":"ノルエピネフリン"},{"subitem_subject":"左室拡張障害"},{"subitem_subject":"K201"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討"}]},"item_type_id":"2","owner":"3","path":["49"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"764","relation_version_is_last":true,"title":["左室拡張障害の発生とその予防に関する実験的検討 : ラット陳旧性梗塞心による検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:16:19.878448+00:00"}