{"created":"2023-06-20T14:25:35.578527+00:00","id":765,"links":{},"metadata":{"_buckets":{"deposit":"fbd632ad-2b58-49c5-80ed-59f8dcc44fa3"},"_deposit":{"created_by":3,"id":"765","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"765"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000765","sets":["81:49"]},"author_link":["3189"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"62","bibliographicPageStart":"T55","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"近年強皮症の皮膚硬化に対するPUVA 療法(8-methoxypsoralen(8-MOP)投与後,長波長紫外線(UVA)を照射する方法)の有効性が数多く報告されているが,この治療による皮膚硬化改善のメカニズムは不明である.我々は正常および強皮症患者真皮由来培養線維芽細胞のI型,III型コラーゲン合成能とコラゲナーゼ遺伝子発現に対する8-methoxypsoralen(8-MOP)存在下UVA 照射の効果を検討した.8-MOP存在下UVA照射は正常人および強皮症患者線維芽細胞ともにI 型,III 型コラーゲン合成とこれらのmRNA レベルをUVA照射量依存性に減少させ,一方でコラゲナーゼ遺伝子発現は不変のままであった.コラーゲン合成の抑制が皮膚硬化に対するPUVA 療法の有効性のメカニズムの1つであることが示唆された.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学皮膚科学"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"8-methoxypsoralen ソンザイカ UVA ショウシャ ノ セイジョウ オヨビ キョウヒショウ センイ ガサイボウ ノ Iガタ, IIIガタ コラーゲン ゴウセイ ノウ ニ タイスル コウカ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"北村, 洋平"},{"creatorName":"キタムラ, ヨウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006358680.pdf","filesize":[{"value":"379.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006358680.pdf","url":"https://dmu.repo.nii.ac.jp/record/765/files/KJ00006358680.pdf"},"version_id":"d4153a43-4672-48f6-9d1b-d4896b762604"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"UVA 照射"},{"subitem_subject":"8-methoxypsoralen"},{"subitem_subject":"コラーゲン合成"},{"subitem_subject":"強皮症"},{"subitem_subject":"線維芽細胞"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"8-methoxypsoralen存在下UVA照射の正常および強皮症線維芽細胞のI 型,III型コラーゲン合成能に対する効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"8-methoxypsoralen存在下UVA照射の正常および強皮症線維芽細胞のI 型,III型コラーゲン合成能に対する効果"}]},"item_type_id":"2","owner":"3","path":["49"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"765","relation_version_is_last":true,"title":["8-methoxypsoralen存在下UVA照射の正常および強皮症線維芽細胞のI 型,III型コラーゲン合成能に対する効果"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:16:22.190606+00:00"}