{"created":"2023-06-20T14:25:35.904892+00:00","id":770,"links":{},"metadata":{"_buckets":{"deposit":"d20b24f6-9647-4b95-b4c5-f67ade0f8ce1"},"_deposit":{"created_by":3,"id":"770","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"770"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000770","sets":["81:50"]},"author_link":["3192","3193"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"82","bibliographicPageStart":"75","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"虚血性心疾患の治療において経皮的冠動脈形成術(percutaneous coronary intervention:PCI)は有用な治療であるが再狭窄が問題である.糖尿病は再狭窄の独立した要因であり,近年インスリン抵抗性が注目されている.今回我々はインスリン抵抗性をHomeostasis Model Assessment 指数(HOMA-R)を用いて評価し,インスリン抵抗性と再狭窄について検討した.2004年8月より2007年12月までにPCIを施行した189例についてHOMA-Rを計測しインスリン抵抗性を認める群(P群:n=124)と認めない群(N群:n=65)にわけ再狭窄について検討した.再狭窄率はP 群で16.9%,N 群で3.1 %と有意差を認めた(p=0.0056).HbA1c 6.5%未満の非糖尿病群においてもP 群13.9%,N 群3.8 %と有意差を認めた(p=0.048).定量的冠動脈造影でも慢性期最小血管径でP 群2.21± 0.91 mmとN 群2.59 mm ±0.57 mm (p=0.031),% stenosisでP 群24.5±26.9%とN群12.0±9.1%( p=0.010),晩期損失径でP群0.815±0.86 mmとN群0.418±0.471 mmと有意差を認めた(p=0.015).HOMA-Rは再狭窄の簡便かつ有用な指標でありインスリン抵抗性を改善させることが再狭窄の減少につながりうる.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"INTRODUCTION & HYPOTHESIS:Percutaneous coronaryintervention( PCI) has been widely adopted as an effectivetreatment strategy for patients with ischemic heartdisease;however, the rate of restenosis is high. Diabetesmellitus has been reported as an independent factor of restenosis.The aim of this study is to clarify the factors associatedwith coronary restenosis after PCI and evaluate thehomeostasis model assessment of insulin resistance (HOMA-R) index as a predictor of restenosis. We reserchedthe clinical records of 189 patients who had been subjectedto elective PCI between August 2004 and December 2007.We distributed these patients by the value of HOMA-Rinto a Group P (n=124;HOMA-R &#8805; 2.5, positive) and aGroup N (n=65;HOMA-R < 2.5, negative). Then, wemeasured the minimal lumen diameter (MLD) and late lumenloss by quantitative coronary angiography( QCA).RESULTS:The rate of restenosis was significantlyhigher in group P (16.9 %) than in group N (3.1 %, p <0.05). In non-diabetic patients whose hemoglobin A1c wasless than 6.5 %, patients with a positive HOMA-R indexwas significantly greater than negative (13.9 vs 3.8 %, p <0.05). In group P the MLD was significantly smaller (2.21±0.91 vs 2.59 ± 0.57 mm, p < 0.05), and the late lumen lossand% stenosis were significantly larger( 0.82±0.86 vs 0.42±0.47 mm, and 24.5±26.9% vs 12.0±9.1%, respectively, p<0.05). The logistic analysis showed that the only independentpredictor of restenosis was insulin resistance (OR6.42;95 % CI 1.46-28.33, p < 0.014).CONCLUSION:We suggest that the HOMA-R index iseasy to calculate and a useful predictor of restenosis;furthermore,improvement of insulin resistance may contributeto prevent coronary restenosis after PCI.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院循環器内科"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Homeostasis Model Assessment シスウ オ モチイタ インスリン テイコウセイ ニヨル カンドウミャク ケイセイジュツゴ サイキョウサク ノ ケントウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小松, 孝昭"},{"creatorName":"コマツ, タカアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3192","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Komatsu, Takaaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"3193","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006360280.pdf","filesize":[{"value":"446.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006360280.pdf","url":"https://dmu.repo.nii.ac.jp/record/770/files/KJ00006360280.pdf"},"version_id":"68095198-5368-40bd-85a9-c9404b7623dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"インスリン抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"Homeostasis Model Assessment 指数(HOMA-R)","subitem_subject_scheme":"Other"},{"subitem_subject":"経皮的冠動脈形成術(PCI)","subitem_subject_scheme":"Other"},{"subitem_subject":"再狭窄(restenosis)","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Homeostasis model assessment of insulin resistance( HOMA-R)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Percutaneous coronary intervention (PCI)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Restenosis ","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Homeostasis Model Assessment指数を用いたインスリン抵抗性による冠動脈形成術後再狭窄の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Homeostasis Model Assessment指数を用いたインスリン抵抗性による冠動脈形成術後再狭窄の検討"},{"subitem_title":"Evaluation of Homeostasis Model Assessment of Insulin Resistance( HOMA-R) Index as a Predictor of Restenosis after Percutaneous Coronary Intervention","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["50"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"770","relation_version_is_last":true,"title":["Homeostasis Model Assessment指数を用いたインスリン抵抗性による冠動脈形成術後再狭窄の検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:16:31.962009+00:00"}