{"created":"2023-06-20T14:25:38.044047+00:00","id":807,"links":{},"metadata":{"_buckets":{"deposit":"2498656f-3de7-4597-9571-f10bf2c05bdc"},"_deposit":{"created_by":3,"id":"807","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"807"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000807","sets":["81:51"]},"author_link":["7021","7022","3418","7020","7024","4720","7023"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"134","bibliographicPageStart":"131","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"PURPOSE:The aim of this study was to investigate changes in spleen size, the level of chromogranin Aas a tumor marker, and the relationship between these two parameters before and 3 months after selectiveinternal radiation therapy (SIRT) for non-resectable liver metastases from neuroendocrine tumor (NET).Our first serious adverse event with this relatively new treatment is also discussed.METHODS:A retrospective review of a prospective database identified patients with non-resectable livermetastases from NET who underwent SIRT between 2003 and 2007. Patients who underwent CT scansbefore and 3 months after treatment were included. The patients were divided into two groups:those withand without a 20 % or more increase in splenic volume on the CT scans. The percentages of patients showinga tumor marker response in the two groups were then comparedRESULTS:Fourteen patients were included in the present analysis. A tumor marker response was seenin 6 of 7 patients( 85.7%) who showed an increase in splenic volume of>20%, and in 3 of 7 patients( 42.9%) without an increase in splenic volume (p=0.266). There was one death as a result of oesophageal varicealbleeding due to portal hypertension at 9 months after treatment.CONCLUSION:Splenic enlargement after SIRT may be associated with tumor marker response, althoughthis could not be confirmed statistically in this study due to the small number of patients. Long-termsplenomegaly and portal hypertension may be important complications of SIRT. This issue needs to be investigatedfurther using a larger number of patients and longer follow-up.","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia:Department of Surgery, Teishinkai Hospitals, Ibaraki, Japan"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia"},{"subitem_text_language":"en","subitem_text_value":"Department of Surgery, St. George Hospital, University of New South Wales, Sydney, Australia"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shehata, Mena","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yan, Kenneth","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"King, Julie","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Glenn, Derek","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Quinn, Richard","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morris, David Lawson","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006364179.pdf","filesize":[{"value":"64.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006364179.pdf","url":"https://dmu.repo.nii.ac.jp/record/807/files/KJ00006364179.pdf"},"version_id":"e7673cea-ea76-41dd-961c-08c0ace1b168"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"internal radiation therapy, SIRT, neuroendocrine tumor, liver metastasis, splenomegaly","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["51"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"807","relation_version_is_last":true,"title":["Splenomegaly and Tumor Marker Response Following Selective Internal Radiation Therapy for Non-Resectable Liver Metastases from Neuroendocrine Tumor"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T15:52:15.553846+00:00"}