{"created":"2023-06-20T14:25:39.142818+00:00","id":832,"links":{},"metadata":{"_buckets":{"deposit":"21f61efd-6c05-4a50-b52b-7a8d28f94f65"},"_deposit":{"created_by":3,"id":"832","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"832"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000832","sets":["81:53"]},"author_link":["3580"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"T17","bibliographicPageStart":"T11","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"横紋筋細胞におけるピオグリタゾンとメトホルミンの単独,及び併用投与時の遺伝子変化について解析した.最初に,ヒト横紋筋由来のA673細胞に対して,1 mMのメトホルミンと10 m Mのピオグリタゾンの単独投与群と両剤併用群を作成し一日培養後,各群にマイクロアレイを施行した.対照と比較し,単独及び,併用投与時には1000個を超える遺伝子で2倍以上の発現を認めた.単独投与で発現が増加し,併用で更に増加した遺伝子群を抽出して階層型クラスター解析と優位機能Pathway解析を施行したところ,階層型クラスター解析では,単独時と比較して,併用時で有意なミトコンドリアb 酸化回路の活性化を認めた(p<0.05).また優位機能Pathway解析では,CPT-1A を含むb 酸化関連遺伝子の活性化を認めた.本研究において,両剤の併用は横紋筋細胞のb 酸化回路を賦活化して,より脂肪燃焼・抗肥満的に作用する可能性が示唆された.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"学位申請論文","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(内分泌代謝)"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"メトホルミン ト ピオグリタゾン ノ ヘイヨウ ニヨル ヒト バイヨウ オウモンキン サイボウ ニ オケル イデンシ ヘンカ ノ カイセキ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 裕晶"},{"creatorName":"シミズ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006373219.pdf","filesize":[{"value":"535.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006373219.pdf","url":"https://dmu.repo.nii.ac.jp/record/832/files/KJ00006373219.pdf"},"version_id":"53e0b9f0-ca98-4f6e-aad8-2781b4dd6e65"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"糖尿病"},{"subitem_subject":"横紋筋細胞"},{"subitem_subject":"ピオグリタゾン"},{"subitem_subject":"メトホルミン"},{"subitem_subject":"DNAマイクロアレイ"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"メトホルミンとピオグリタゾンの併用によるヒト培養 横紋筋細胞における遺伝子変化の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"メトホルミンとピオグリタゾンの併用によるヒト培養 横紋筋細胞における遺伝子変化の解析"}]},"item_type_id":"2","owner":"3","path":["53"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"832","relation_version_is_last":true,"title":["メトホルミンとピオグリタゾンの併用によるヒト培養 横紋筋細胞における遺伝子変化の解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:18:11.959673+00:00"}