{"created":"2023-06-20T14:25:39.805067+00:00","id":847,"links":{},"metadata":{"_buckets":{"deposit":"81a0e249-f3c7-4a61-ba70-8fa2dadb5cdd"},"_deposit":{"created_by":3,"id":"847","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"847"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000847","sets":["81:54"]},"author_link":["3638","3637"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"110","bibliographicPageStart":"103","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"末梢の毛細リンパ管は毛細血管と同様に,組織間隙に漏出した血液中の水分,電解質,蛋白質などの細胞外成分を再吸収する働きがあるためリンパ管の機能が障害されると浮腫がおこることは知られている.以前より鼻粘膜にはリンパ管とリンパ網が存在するが,副鼻腔粘膜にはリンパ管があまり発達していないという指摘があった.そのため,副鼻腔におけるリンパ管環流障害によって粘膜浮腫を起こすことが鼻茸における成因の1つの要素ではないかと考えた.鼻茸の中でも後鼻孔鼻茸は上顎洞粘膜から発生して,後鼻孔を閉塞するほど単房性に巨大化するため,通常の副鼻腔炎に伴う鼻茸とは臨床的には区別される.しかし,組織学的な両者の区別については明らかでない.私は,それぞれの鼻茸の発生する粘膜に何か違いがあるのではないかと考え,鼻茸と鼻・副鼻腔粘膜における血管及びリンパ管の分布について検討した.対象の粘膜及び鼻茸は血管内皮細胞に対して特異的な抗体であるCD34とリンパ管内皮細胞に対して特異的な抗体であるD2-40( 抗ポドプラニン抗体)で染色した.1検体につき光学顕微鏡の100倍視野にてそれぞれ5視野ずつカウントし単位面積(1 mm2)あたりのリンパ管数を算出した.その結果後鼻孔鼻茸は他の鼻茸と比較してリンパ管が有意に少なく,また後鼻孔鼻茸の発生する上顎洞も他の鼻・副鼻腔粘膜に比べてリンパ管が有意に少なかった.一方,血管の分布に関して有意差は無かった.このことは,後鼻孔鼻茸が巨大化する要因としてリンパ管が少ないこと,そしてそれは発生母地である上顎洞粘膜にリンパ管がないことが起因していると結論づけた.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Peripheral lymphatic capillaries act to reabsorb intercellularcomponents such as interstitial fluid, electrolytes andproteins that leak from the vessels. Hence, it is known thatimpairment of the function of these lymphatic vessels canlead to edemas. Previous research has demonstrated thepresence of lymph vessels and lymph networks in the nasalmucosa, but little development of lymph vessels in the paranasalsinus mucosa. Therefore, we hypothesized that mucousmembrane edema caused by impaired lymph vesseldrainage in the paranasal sinus may be one causative factorfor nasal polyps.Antrochoanal polyps are unilateral and arise from themaxillary sinus mucosa. They enlarge in a unilocular fashionsuch that they block the posterior nasal aperture, so inclinical terms they can be differentiated from nasal polypsaccompanying general sinusitis. In histological terms, however,the two conditions cannot be clearly differentiated. Isurmised that there might be some difference in the mucousmembranes where each type of nasal polyp occurs,and investigated the distribution of nasal polyps and oflymph vessels and blood vessels in the nasal and paranasalsinus mucosa.The mucous membranes and nasal polyps under studywere stained with an anti-podoplanin antibody (D2-40)that is specific for lymph vessel endothelial cells and theantibody CD34 that is specific for vascular endothelial cells.Each test sample was observed under a light microscopeand five fields of view at 100x magnification were countedto give the number of lymph vessels per unit area( 1 mm2).The results showed that antrochoanal polyps had significantlyfewer lymph vessels compared with other nasal polyps.Moreover, the maxillary sinus where the antrochoanalpolyps arise also had significantly fewer lymph vessels comparedwith the nasal and paranasal sinus mucosa. In contrast,no significant differences were seen in blood vesseldistribution. In conclusion, the low number of lymph vesselsmay be one factor involved in the enlargement of antrochoanalpolyps, and this may be due to the lack of lymph vesselsin the maxillary sinus mucosa where the antrochoanalpolyps develop.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学越谷病院耳鼻咽喉科"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Otorhinolaryngology, Dokkyo Medical University Koshigaya Hospital"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"コウビコウ ハナタケ ノ キョダイカ ト リンパ カン ブンプ ミツド ニ ツイテ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 洋子"},{"creatorName":"イケダ, ヨウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikeda, Yoko","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006377999.pdf","filesize":[{"value":"456.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006377999.pdf","url":"https://dmu.repo.nii.ac.jp/record/847/files/KJ00006377999.pdf"},"version_id":"77588be6-a28e-441d-9a38-4af558222875"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リンパ管"},{"subitem_subject":"上顎洞粘膜"},{"subitem_subject":"後鼻孔鼻茸"},{"subitem_subject":"antrochoanal polyp","subitem_subject_language":"en"},{"subitem_subject":"lymph vessels","subitem_subject_language":"en"},{"subitem_subject":"maxillarysinus","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"後鼻孔鼻茸の巨大化とリンパ管分布密度について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"後鼻孔鼻茸の巨大化とリンパ管分布密度について"},{"subitem_title":"Enlargement of Antrochoanal Polyps and Density of Lymphatic Vessels","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["54"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"847","relation_version_is_last":true,"title":["後鼻孔鼻茸の巨大化とリンパ管分布密度について"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:18:34.217666+00:00"}