{"created":"2023-06-20T14:25:43.151180+00:00","id":919,"links":{},"metadata":{"_buckets":{"deposit":"32e0f974-63e7-447d-884a-cf6e9a289b4d"},"_deposit":{"created_by":3,"id":"919","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"919"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000919","sets":["81:57"]},"author_link":["4054","4055"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"31","bibliographicPageStart":"25","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"近年若年女性の子宮頸部異形成や上皮内癌などの初期病変が増加傾向にあり,その治療として子宮頸部円錐切除術(円切)が施行されている.円切により子宮頸部浸潤癌の発生を減少させるが,再発した場合浸潤癌へ進展する危険性は高い.そのため治療後の再発を早期に発見することが求められる.今回,当院で円切を施行した226 例において,円切前後におけるhuman papillomavirus(HPV)感染と外科断端陰性例での再発との関連性を検討した.術前のHPV 陽性率は97.3%(220/226 例)であり,HPV16 型が最も多く44.5%を占めた.HPV 陽性220 例中54 例(25.4%)に術後HPV 陽性が持続し,HPV 陰性例に比して再発率が有意に高かった(p<0.01).また,外科断端陰性の181 例においても,円切後HPV が持続した例での再発率が有意に高かった(p<0.01).さらに円切後HPV 陽性の外科断端陰性例において,円切前後で同じ型のHPV が持続した例では有意に再発率が高かった(p<0.01).以上より,円切後HPV 陽性及びHPV の型(同一)は再発のリスク因子であり,円切後のフォローアップに細胞診のみでなくHPV 検査及び型検索を併用して行うことが重要である.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"This clinical study was done to investigate a potential relationshipbetween human papillomavirus (HPV) infectionand disease relapses in patients who received therapeuticconization under the diagnosis of cervicalintraepithelial neoplasia(CIN) or microinvasive carcinoma. Two hundred andtwenty six patients with cervical neoplastic diseases(CIN2;4, CIN3;211 and stage Ia1 carcinoma;11) wereinvolved in this study.Of these 226 patients, 220(97.3 %) were positive for HPVDNA in their cervical lesions prior to conization. HPV 16DNA was detected in 98 of 220 patients (44.5 %), and, accordingly,concluded to be most common. HPV DNA wasalso detected even after conization in 54 of those 220 HPVDNA-detected cases( 24.5%). In 16 of those 54 cases( 29.6%), CIN or microinvasive carcinoma relapsed, while thediseases did in only 6 of those 166 cases (3.6 %), whereHPV DNA became persistently negative after conization( p<0.01). Even in the cases where the surgical margin washistologically negative by conization, the relapse rate wassignificantly higher in the HPV-persisting patients than inthe HPV-vanishing ones (p<0.01). In addition, the caseswith the same type of HPV-persistence before and afterconization showed the significantly higher relapse rate thanthose with the different types of HPV-persistence (p<0.01).Thus, the author suggests strongly that we should followthe patients with the same type of HPV-persistence beforeand after conization intensively.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"豊見城中央病院産婦人科 : 獨協医科大学産科婦人科学"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Devision of Obstetrics and Gynecology, Tomishiro central Hospital : Department of Obstetrics and Gynecology, Dokkyo Medical University"}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"シキュウ ケイブ ジョウヒ ナイ シュヨウ ・ ケイガン ノ エンスイ セツジョ ゲカ ダンタン インセイ レイ ニオケル Human Papillomavirus ケンサ ノ ユウヨウセイ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上地, 秀昭"},{"creatorName":"ウエチ, ヒデアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4054","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uechi, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"4055","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006979179.pdf","filesize":[{"value":"249.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006979179.pdf","url":"https://dmu.repo.nii.ac.jp/record/919/files/KJ00006979179.pdf"},"version_id":"d00708d6-4df9-4bde-8ba6-5d77225e2f34"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"子宮頸部上皮内腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"子宮頸部円錐切除術","subitem_subject_scheme":"Other"},{"subitem_subject":"HPV 感染","subitem_subject_scheme":"Other"},{"subitem_subject":"再発","subitem_subject_scheme":"Other"},{"subitem_subject":"HPV 型検索","subitem_subject_scheme":"Other"},{"subitem_subject":"cervical intraepithelial neoplasia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HPV infection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"recurrence","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HPV typing","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"子宮頸部上皮内腫瘍・頸がんの円錐切除外科断端陰性例におけるHuman Papillomavirus 検査の有用性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮頸部上皮内腫瘍・頸がんの円錐切除外科断端陰性例におけるHuman Papillomavirus 検査の有用性"},{"subitem_title":"Clinical Significance of Human Papillomavirus Tests before and after Therapeutical Conization for Cervical Intraepithelial Neoplasia or Microinvasive Carcinoma:With Special Reference to Post-conization Relapses","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["57"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"919","relation_version_is_last":true,"title":["子宮頸部上皮内腫瘍・頸がんの円錐切除外科断端陰性例におけるHuman Papillomavirus 検査の有用性"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:07:26.313589+00:00"}