{"created":"2023-06-20T14:25:43.330994+00:00","id":923,"links":{},"metadata":{"_buckets":{"deposit":"0995a2d0-8c51-4f8b-a3f5-511dca834b49"},"_deposit":{"created_by":3,"id":"923","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"923"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000923","sets":["81:57"]},"author_link":["4122","4127","4124","4125","4126","4131","4133","4135","4116","4128","4134","4121","4123","4120","4132","4129","4130","4118","4117","4119"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"64","bibliographicPageStart":"59","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Human papillomavirus (HPV) 中高リスク型の感染が,子宮頸部の前癌病変や子宮頸癌の発症に関与していることが明らかにされた.HPV 感染の一部は持続感染し,子宮頸癌のリスクとなる.そこでHPV 感染状況と子宮頸癌検診における細胞診とHPV 検査併用の意義について検討した.対象は3 年以上経過観察可能であった細胞診正常81 例と細胞診異常で組織診を施行した80 例である.HPV 検出にはHybrid Capture AssayII®( HC-II®) 法を用いた.細胞診正常11 例,細胞診異常61 例でHPV が検出され,細胞診異常の程度が進むほどHPV 検出率は上昇した.組織診でも病変が進行するほどHPV 検出率は高くなった.細胞診正常ではHPV陽性持続で病変の進行を認めた.組織診別では,慢性子宮頸管炎(Chronic Cervicitis:CC) ではHPV 陽性持続1 例と陽性化1 例に,子宮頸部上皮内病変(Cervical Intraepithelial Neoplasia:CIN) IではHPV 陽性持続2 例に,CIN IIでは陽性持続3 例と陽性化した1 例に,CIN IIIでは陽性持続2 例に病変の進行が認められた.HPV 感染が認められなかった例では病変の進行を認めない結果から,細胞診とHPV 検査を併用することにより,細胞診正常でHPV 検査陰性であれば検診間隔を3 年に延ばすことが可能であると示唆された.またHPV持続感染が病変進行の原因となると考えられ,HPV 検査の導入は子宮頸癌の早期発見,早期治療に有用である.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"Persistent infection with intermediate or high risk subtypesof human papillomavirus (HPV) is associated withuterine cervical neoplasia and cervical cancer. Over a3-year period, we followed up 161 patients with normal( 81cases) and abnormal (80 cases) results of cytologicalscreening tests to determine the status of persistent HPVinfection and the significance of combined uterine cervicalcancer cytological screenings and HPV tests. The hybridcapture assay II® method was used to test for intermediateor high risk of HPV infection. HPV infection was detectedin 11 patients with normal results and 61 patients with abnormalresults of cytological screening tests. The positiverate of HPV infection was associated with the status of cytologicaland pathological lesion progression. Lesions of 2patients with persistent HPV infection who had normal resultsin cytological screening tests had been diagnosed withprogressive lesions. Lesions of patients in whom HPV infectionwas negative or negative conversion were determinedto be non-progressive. Disease progression was seen in theform of chronic cervicitis in 1 patient with persistent HPVinfection and 1 patient with HPV positive conversion;inthe form of cervical intraepithelial neoplasia (CIN) I in 2patients with persistent HPV infection;in the form of CINII in 3 patients with persistent HPV infection and 1 patientwith HPV positive conversion;and in the form of CIN IIIin 2 patients with persistent HPV infection. In conclusion,combined cytological screening and HPV tests will increasethe precision of uterine cervical cancer screening and willbe valuable for the early detection and a rapid treatment ofuterine cervical cancer. Moreover, the interval between 2consecutive uterine cervical cancer screenings can be extendedto at least 3 years in patients who have normal resultsof cytology and no HPV infection.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"Original","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"},{"subitem_text_value":"獨協医科大学産科婦人科学"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University"},{"subitem_text_language":"en","subitem_text_value":"Department of Obstetrics and Gynecology, Dokkyo Medical University "}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"HPV カンセン ジョウキョウ ト シキュウ ケイガン ケンシン ニオケル サイボウ シン ト HPV ケンサ ヘイヨウ ノ イギ "}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"香坂, 信明"},{"creatorName":"コウサカ, ノブアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡崎, 隆行"},{"creatorName":"オカザキ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"稲葉, 未知世"},{"creatorName":"イナバ, ミチヨ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"稲葉, 不知之"},{"creatorName":"イナバ, フジユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"亀森, 哲"},{"creatorName":"カメモリ, テツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"坂本, 尚徳"},{"creatorName":"サカモト, タカノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北澤, 正文"},{"creatorName":"キタザワ, マサフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"渡辺, 博"},{"creatorName":"ワタナベ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"深澤, 一雄"},{"creatorName":"フカサワ, イチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"稲葉, 憲之"},{"creatorName":"イナバ, ノリユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kosaka, Nobuaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okazaki, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaba, Michiyo","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaba, Fujiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kamemori, Tetsu","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakamoto, Takanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitazawa, Masafumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukasawa, Ichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inaba, Noriyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00006983500.pdf","filesize":[{"value":"349.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00006983500.pdf","url":"https://dmu.repo.nii.ac.jp/record/923/files/KJ00006983500.pdf"},"version_id":"16ebe5f1-ed28-464b-b36a-e6142bd33689"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human papillomavirus(HPV)"},{"subitem_subject":"Hybrid Capture Assay II®( HC-II®)法"},{"subitem_subject":"Cervical Intraepithelial Neoplasia(CIN)"},{"subitem_subject":"細胞診"},{"subitem_subject":"子宮頸癌検診"},{"subitem_subject":"Human papillomavirus(HPV)","subitem_subject_language":"en"},{"subitem_subject":"Hybrid Capture Assay II®( HC-II®)","subitem_subject_language":"en"},{"subitem_subject":"Cytology","subitem_subject_language":"en"},{"subitem_subject":"Cervical intraepithelial neoplasia(CIN)","subitem_subject_language":"en"},{"subitem_subject":"Cervical cancer screening","subitem_subject_language":"en"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HPV 感染状況と子宮頸癌検診における細胞診とHPV 検査併用の意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HPV 感染状況と子宮頸癌検診における細胞診とHPV 検査併用の意義"},{"subitem_title":"Human Papillomavirus(HPV)Infection and the Significance of Combined Cytology and HPV Test in Uterine Cervical Cancer Screening","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["57"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"923","relation_version_is_last":true,"title":["HPV 感染状況と子宮頸癌検診における細胞診とHPV 検査併用の意義"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T15:52:20.327330+00:00"}