{"created":"2023-06-20T14:25:46.648733+00:00","id":998,"links":{},"metadata":{"_buckets":{"deposit":"91a0f372-7105-4a78-9d71-428167bc61d2"},"_deposit":{"created_by":3,"id":"998","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"998"},"status":"published"},"_oai":{"id":"oai:dmu.repo.nii.ac.jp:00000998","sets":["81:61"]},"author_link":["4645","4647","4648","4643","4644","4646"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"43","bibliographicPageStart":"37","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Dokkyo journal of medical sciences"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"Apo-E KO マウス( ApoE-/-) を用いて,コレステロール吸収阻害薬のezetimibe( EZ) とHMG-CoAreductase 阻害薬のfluvastatin( Fluva) の動脈硬化形成に与える影響について検討した.高脂肪食負荷ApoE-/- マウスではEZ の投与により,総コレステロールおよびLDL コレステロールをそれぞれ63%,74%減少させ,胸部大動脈のプラーク形成を明らかに抑制するとともに,内皮依存性の血管弛緩反応を有意に改善した.一方,Fluva 投与ではその効果が認められなかった.また,EZ 投与はmonocyte chemoattractantprotein-1,vascular cell adhesion molecule-1,intercellular adhesion molecule-1 などの白血球走化・接着因子やNADPH oxidase コンポーネントの肺組織中mRNA 発現を有意に抑制した.高脂肪食負荷ApoE-/- マウスにおいて,EZ は明らかな抗動脈硬化作用を示した.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"The aim of present study was to investigate the effects ofezetimibe, a cholesterol absorption inhibitor, on athrosclerosisin apolipoprotein E knockout (ApoE-KO) mice. Tretmentwith ezetimibe, but not fluvastatin, significantly Decreased serum total and low density lipoprotein (LDL)Cholesterol and lesions of atherosclerotic plaque of aorta Inwastern diet-fed ApoE-KO mice. Ezetimibe also restorednitric oxide-mediated vascular relaxation in isolated aorticrings.Moreover, ezetimibe treatment significantly decreased the mRNA expression of a chemoattractant, adhesion molecules,and several subunits of NADPH oxidase in lung tissues.These results suggest that ezetimibe may inhibit athrosclerosis by ameliorating vascular inflammation and oxidative stress in ApoE-KO mice independently of lowering serum cholesterol level.","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00629581"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03855023","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"獨協医科大学内科学(内分泌代謝)"},{"subitem_text_value":"獨協医科大学薬理学"},{"subitem_text_value":"獨協医科大学内科学(内分泌代謝) "}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine."},{"subitem_text_language":"en","subitem_text_value":"Department of Pharmacology, Dokkyo Medical University School of Medicine."},{"subitem_text_language":"en","subitem_text_value":"Department of Endocrinology and Metabolism, Dokkyo Medical University School of Medicine."}]},"item_2_title_3":{"attribute_name":"論文名よみ","attribute_value_mlt":[{"subitem_title":"Apo-E KO( ApoE-/-) マウス ニオケル Ezetimibe ノ コウ ドウミャク コウカ サヨウ"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"助川, 敦子"},{"creatorName":"スケガワ, アツコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内田, 幸介"},{"creatorName":"ウチダ, コウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"城島, 輝雄"},{"creatorName":"ジョウジマ, テルオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sukegawa, Atsuko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uchida, Kosuke","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Jojima, Teruo","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-05-24"}],"displaytype":"detail","filename":"KJ00007846059.pdf","filesize":[{"value":"400.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00007846059.pdf","url":"https://dmu.repo.nii.ac.jp/record/998/files/KJ00007846059.pdf"},"version_id":"b9e95e77-5ba0-4efc-be04-5dea811b9636"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エゼチミブ"},{"subitem_subject":"抗動脈硬化作用"},{"subitem_subject":"高脂肪食APO-E KO (ApoE-/-) マウス"},{"subitem_subject":"酸化ストレス"},{"subitem_subject":"血管内皮障害"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用"},{"subitem_title":"Anti-Atherogenic Effect of Eztimibe in Apo-E Knockout Mice","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["61"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-05-24"},"publish_date":"2017-05-24","publish_status":"0","recid":"998","relation_version_is_last":true,"title":["Apo-E KO( ApoE-/-) マウスにおけるEzetimibe の抗動脈硬化作用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T16:03:29.195408+00:00"}