{"_buckets": {"deposit": "9c88d8be-db4b-4720-9ae4-f8efaef6afaf"}, "_deposit": {"created_by": 3, "id": "1080", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1080"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001080", "sets": ["65"]}, "author_link": ["5059", "5065", "5060", "5061", "5064", "5063", "5062", "5058"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "16", "bibliographicPageStart": "9", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "Background and Objective:To clarify the clinical characteristics of acute exacerbation of idiopathic pulmonaryfibrosis (IPF) and the involvement of infections with pathogenic microorganisms and viruses inacute exacerbation.Methods:During the 12 years from 2000 through 2011, we studied 50 patients who were admitted andreceived treatment for acute exacerbation of IPF in our department. Demographic characteristics, imagingfindings, laboratory findings, changes in antibody titers against bacteria, Mycoplasma pneumoniae, Chlamydophilapneumoniae, and known viruses, and outcomes were studied.Results:Among the 50 patients with acute exacerbation of IPF( 41 men and 9 women) 29 patients died(mortality rate, 58.0%). Computed tomography showed subpleural peripheral ground-glass opacities( GGO)in 5 patients, multiple patchy GGO in 19, and diffuse GGO in 26. Only the PaO2/FiO2 ratio was significantlylower in the non-survivors compared with survivors. Three patients had high titers of IgM antibodiesagainst C. pneumoniae, but acute infection was ruled out by the changes in IgA and IgG antibodies in pairedserum samples. Antibody titers against known viruses significantly increased in 2 patients( respiratory syncytialvirus in 1 and adenovirus 11 in 1). In acute-phase serum samples, 7 patients had increased antibodytiters against parainfluenza virus 3, resulted in no significant change in paired serum samples.Conclusions:Our results suggest that known pathogens do not play a role in acute exacerbation of IPF.The outcomes of IPF remain poor, and the elucidation of the causes and pathological features of acute exacerbationof IPF, including the identification of unknown pathogens, is awaited.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "3", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00008416179", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Pulmonary Medicine and Clinical Immunology, Dokkyo Medical University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Clinical Characteristics of Acute Exacerbations of Idiopathic Pulmonary Fibrosis and Involvement of Viral, Mycoplasma pneumoniae, and Chlamydophila pneumoniae Infections"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Anzai, Makiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5058", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukushima, Yasutsugu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5059", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Obara, Kazuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5060", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuno, Kazuhiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5061", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kikkawa, Yasuko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5062", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Hirokuni", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5063", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiyama, Kumiya", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5064", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fukuda, Takeshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5065", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00008416179.pdf", "filesize": [{"value": "257.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 257899.99999999997, "url": {"label": "KJ00008416179.pdf", "url": "https://dmu.repo.nii.ac.jp/record/1080/files/KJ00008416179.pdf"}, "version_id": "6d618ca1-7a2c-47a1-aff8-da6df05c79e7"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "acute exacerbation", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Chlamydophila pneumoniae", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "idiopathic pulmonary fibrosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mycoplasma pneumoniae", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "viral infection", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Clinical Characteristics of Acute Exacerbations of Idiopathic Pulmonary Fibrosis and Involvement of Viral, Mycoplasma pneumoniae, and Chlamydophila pneumoniae Infections", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Clinical Characteristics of Acute Exacerbations of Idiopathic Pulmonary Fibrosis and Involvement of Viral, Mycoplasma pneumoniae, and Chlamydophila pneumoniae Infections", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["65"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/1080", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "1080", "relation": {}, "relation_version_is_last": true, "title": ["Clinical Characteristics of Acute Exacerbations of Idiopathic Pulmonary Fibrosis and Involvement of Viral, Mycoplasma pneumoniae, and Chlamydophila pneumoniae Infections"], "weko_shared_id": 3}