{"_buckets": {"deposit": "cfea3b3b-a328-4083-b0e8-5edd46561b98"}, "_deposit": {"created_by": 3, "id": "1099", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1099"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001099", "sets": ["66"]}, "author_link": ["5194", "5208", "5189", "5195", "5203", "5204", "5191", "5210", "5193", "5197", "5207", "5192", "5200", "5196", "5199", "5205", "5202", "5190", "5198", "5201", "5206", "5209"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2013-07-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "103", "bibliographicPageStart": "95", "bibliographicVolumeNumber": "40", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "目的:虚血性心疾患に対する経皮的冠動脈形成術(Percutaneous coronary intervention:PCI)は有用な治療法として確立されている.薬剤溶出性ステント(Drug-eluting stent:DES)により,大きな問題であった再狭窄は減少したが,完全には克服されていない.最近糖尿病の前段階としてインスリン抵抗性が注目されており,再狭窄に影響を及ぼすことが示唆されている.今回我々はHomeostasis Model Assessment 指数(HOMA-IR)を用いてインスリン抵抗性の程度とDES 留置後の再狭窄の関連を検討した.方法:2007 年5 月から2010 年10 月までに待機的にPCI を施行しDES を留置した248 例について,HOMAIRより高度インスリン抵抗性を有する群(H 群:n=75)と中等度インスリン抵抗性を有する群(M 群:n=64)およびインスリン抵抗性を有さない群(L 群:n=109)に分類し,定量的冠動脈造影を用いて再狭窄率および再狭窄関連因子について検討した.結果:再狭窄率はH 群で有意に高かった(p=0.0005).慢性期最小血管径はH 群で他の2 群と比較して有意に小さかった(H:1.62±1.02 mm,M:2.42±0.48 mm,L:2.17±0.70 mm, p=0.0086).さらに%狭窄率はH 群で他の2 群と比較して有意に大きく(H:40.1±34.7%,M::14.7±10.4%,L:22.7±21.6%, p=0.0092),晩期損失径もH 群で他の2 群と比較して有意に大きかった(H:0.87±0.90 mm,M:0.19±0.17 mm,L:0.41±0.62 mm, p=0.0097).結論:高度インスリン抵抗性は,DES 留置後再狭窄の危険因子となりえると考えられた.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "INTRODUCTION: Percutaneous coronary intervention (PCI) has beenwidely adopted as an effective treatment strategy for patientswith ischemic heart disease;especially, restenosis issuppressed after drug-eluting stent (DES) implantation.However, coronary artery restenosis after DES implantationstill appear now and then. The aim of this study was toclarify the factors associated with coronary artery restenosisafter DES implantation and evaluate the homeostasismodel assessment of insulin resistance (HOMA-IR) indexas a predictor of restenosis.METHODS: We reserched the clinical records of 248 patients who hadbeen subjected to elective PCI and DES implantation betweenMay 2007 and December 2010. We divided these patientsby the value of HOMA-IR into three groups(GroupH;HOMA-IR≧5 . 0 , Group M;2 . 5≦HOMA-IR\u003c5 . 0 ,Group L;2.5\u003eHOMA-IR), and examined the relationshipbetween coronary artery restenosis and HOMA-IR.RESULTS: The rate of restenosis was significantly higher in GroupH (26.7 %) than in the other two groups (M;7.8 % andL;8.3%, p=0.0005 %). Follow up MLD was significantlylower in Group H (H;1.62±1.02 mm v.s. M;2.42±0.48 mm v.s. L;2.17±0.70 mm, p=0.0086). Furthermore, %stenosis and late lumen loss was significantly higher inGroup H (H;40.1±34.7%, M;14.7±10.4%, L;22.7±21.6%, p=0.0092, and H;0.87±0.9 mm v.s. M;0.19±0.17 mmv.s. L;0.41±0.62 mm, P=0.0097). Logistic analysis showedthat the only independent predictor of restenosis was HOMA-IR over 5.0( OR 2.87;p=0.004).CONCLUSION: The results suggested that severe insulin resistance wasa predictor of restenosis after drug-eluting stent implantation;furthermore, that improvement of insulin resistancemay contribute to prevent coronary restenosis after drugelutingstent implantation.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "4", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00008665659", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}, {"subitem_text_value": "獨協医科大学越谷病院循環器内科"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Cardiology, Dokkyo Medical University Koshigaya Hospital"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "コウド インスリン テイコウセイ ジョウタイ ニ オケル ヤクザイ ヨウシュツセイ ステント リュウチ ゴ サイキョウサク ノ ヨソク インシ ノ ケントウ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "由布, 哲夫"}, {"creatorName": "ユフ, テツオ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5189", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小松, 孝昭"}, {"creatorName": "コマツ, タカアキ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5190", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "谷口, 勲"}, {"creatorName": "ヤグチ, イサオ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5191", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "黒柳, 享義"}, {"creatorName": "クロヤナギ, タカノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5192", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤掛, 彰則"}, {"creatorName": "フジカケ, アキノリ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5193", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "小松, 禎子"}, {"creatorName": "コマツ, サチコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5194", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "尾崎, 文武"}, {"creatorName": "オザキ, フミタケ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5195", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中村, 日出彦"}, {"creatorName": "ナカムラ, ヒデヒコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5196", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "東, 昭宏"}, {"creatorName": "ヒガシ, アキヒロ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5197", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "酒井, 良彦"}, {"creatorName": "サカイ, ヨシヒコ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5198", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高柳, 寛"}, {"creatorName": "タカヤナギ, カン", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5199", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yufu, Tetsuo", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5200", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Takaaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5201", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yaguchi, Isao", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5202", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroyanagi, Takanori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5203", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujikake, Akinori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5204", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Komatsu, Sachiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5205", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ozaki, Fumitake", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5206", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Hidehiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5207", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higashi, Akihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5208", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sakai, Yoshihiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5209", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takayanagi, Kan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5210", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00008665659.pdf", "filesize": [{"value": "449.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 449000.0, "url": {"label": "KJ00008665659.pdf", "url": "https://dmu.repo.nii.ac.jp/record/1099/files/KJ00008665659.pdf"}, "version_id": "30626954-53ed-4072-abef-4f16812a3556"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "インスリン抵抗性", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HOMA-IR", "subitem_subject_scheme": "Other"}, {"subitem_subject": "再狭窄", "subitem_subject_scheme": "Other"}, {"subitem_subject": "薬剤溶出性ステント", "subitem_subject_scheme": "Other"}, {"subitem_subject": "内膜増殖", "subitem_subject_scheme": "Other"}, {"subitem_subject": "insulin resistance", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HOMA-IR", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "restenosis", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Drug-eluting stent", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "intimal hyperplasia", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "高度インスリン抵抗性状態における薬剤溶出性ステント留置後再狭窄の予測因子の検討", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "高度インスリン抵抗性状態における薬剤溶出性ステント留置後再狭窄の予測因子の検討"}, {"subitem_title": "Severe Insulin Resistance is a Predictor of Restenosis after Drug-eluting Stent Implantation", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["66"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/1099", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "1099", "relation": {}, "relation_version_is_last": true, "title": ["高度インスリン抵抗性状態における薬剤溶出性ステント留置後再狭窄の予測因子の検討"], "weko_shared_id": 3}