| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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言語 |
en |
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主題 |
protein induced by vitamin K absence or antagonist II( PIVKA-II) |
| キーワード |
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言語 |
en |
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主題 |
NX-PVKA-R |
| キーワード |
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言語 |
en |
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主題 |
hepatocellular carcinoma |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Positioning of novel tumor marker NX-PVKA-R in the diagnosis of hepatocellular carcinoma in comparison with PIVKA-II |
| 著者 |
Suzuki, Kazuyoshi
Tamano, Masaya
Kuniyoshi, Toru
Katayama, Yasumi
Takada, Hiroshi
Suzuki, Kazutomo
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| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
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en |
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Department of Gastroenterology, Dokkyo Medical University Koshigaya Hospital |
| 記事種別(英) |
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内容記述タイプ |
Other |
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内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
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内容記述 |
Background/Aims:To compare the use of protein induced by vitamin K absence or antagonist II( PIVKA-II) measured conventionally with the ratio between PIVKA-II measured using P-11 and P-16 antibodies(NX-PVKA) and PIVKA-II measured conventionally (NX-PVKA-R) in terms of false-positive resultsfor hepatocellular carcinoma( HCC). Methodology:Subjects comprised 318 patients with chronic liver disease,including 8 patients receiving warfarin treatment, which can result in false-positive results for HCC.HCC was present in 65 patients (HCC group) and absent in 253 (non-HCC group). PIVKA-II was measuredconventionally. NX-PVKA-R was calculated as PIVKA-II/NX-PVKA. Results:Both PIVKA-II andNX-PVKA-R were significantly higher in the HCC group than in the non-HCC group (p<0.0001 each).False-positive results were seen in 9.5% of non-HCC patients with PIVKA-II, and in 10.3% with NX-PVKA-R. False-positive results were seen for all 8 patients (100%) on warfarin with PIVKA-II, but for 0%with NX-PVKA-R. Sensitivity, specificity, and accuracy were all lower for NX-PVKA-R than PIVKA-II.Conclusions:NX-PVKA-R is not more useful than PIVKA-II for diagnosing HCC, but is very useful insubpopulations such as patients on warfarin and patients with jaundice. The characteristics of NX-PVKA-Rcan be best exploited by selecting patients in which these factors are present. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 40,
号 3,
p. 163-168,
発行日 2013-10-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00008800279.pdf (259.4 kB)
