{"_buckets": {"deposit": "6078d843-b6ba-484b-8c19-537b9306ba6a"}, "_deposit": {"created_by": 3, "id": "1175", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "1175"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001175", "sets": ["69"]}, "author_link": ["5721", "5722"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2014-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "86", "bibliographicPageStart": "79", "bibliographicVolumeNumber": "41", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_10": {"attribute_name": "抄録(日)", "attribute_value_mlt": [{"subitem_description": "冠動脈ステント後の再狭窄発症にインスリン抵抗性が関与することはわかっているが,インスリン抵抗性改善による再狭窄予防効果は確立されていないことから,本研究でそれを明らかにすることを試みた.待機的に冠動脈ステント術を施行したインスリン抵抗性を有する冠動脈疾患患者82 例を対象とし,ステント術後慢性期にインスリン抵抗性が改善した群(n=54)と増悪した群(n=28)とに分け,定量的冠動脈造影諸量を比較検討した.再狭窄率はインスリン抵抗性改善群で7.4%と悪化群の25.0%に比べ有意に低値であった(p=0.0267).また慢性期最小血管径は改善群で2.52±0.63 mm と悪化群の2.04±0.70 mm に比べ有意に高値(p=0.0021)であり,% diameter stenosis は改善群 18.32±16.89%,悪化群 31.07±26.93%( p=0.0102),晩期損失径は改善群0.17±0.21 mm,悪化群0.32±0.42 mm (p=0.0335)といずれも改善群で有意に低値であった.以上の結果からインスリン抵抗性を改善させることが冠動脈ステント術後再狭窄の予防につながりうることが示唆された.", "subitem_description_type": "Other"}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "PURPOSE:Percutaneous coronary intervention( PCI) is an effective treatment for patients with coronary artery disease. Although restenosis, a major weakness of PCI, has been substantially reduced since drug-eluting stent( DES) was induced, it is still a big hurdle in patients complicated with diabetes. Previously, we reported restenosis was associated with insulin resistance. The aim of this study was to elucidate the effect of improvement of insulin resistance on restenosis reduction. METHODS:Subjects included 82 patients with chronic coronary artery disease and insulin resistance who underwent elective coronary stent implantation. Patients were divided into 2 groups by improved (n=54) or aggravated (n=28) insulin resistance, which was assessed with the homeostasis model assessment (HOMA-IR). Quantitative coronary angiographic parameters were compared between 2 groups of improved and aggravated insulin resistance.RESULTS: The rate of restenosis was significantly lower in the improvement group, compared to the aggravation group (7.4 % vs 25.0 %,p=0.0267). The minimal lumen diameter was significantly larger (2.52±0.63 vs 2.04± 0.70 mm, p=0.0021), the % diameter stenosis was significantly smaller (18.32±16.89 % vs 31.07±26.93 %, p= 0.0102), and the late lumen loss was significantly smaller (0.17±0.21 vs 0.32±0.42 mm, p=0.0335) in the improvement group, compared to the aggravation group.CONCLUSION:These results suggest that improvement of insulin resistance may contribute to prevention of restenosis after coronary stent implantation.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "12", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00009214768", "subitem_description_type": "Other"}]}, "item_2_description_8": {"attribute_name": "記事種別(日)", "attribute_value_mlt": [{"subitem_description": "原著", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_6": {"attribute_name": "著者所属(日)", "attribute_value_mlt": [{"subitem_text_value": "獨協医科大学内科学(心臓・血管)"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department Of Cardiovascular Medicine, Dokkyo Medical University School Of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "インスリン テイコウ セイ カイゼン ニ ヨル カンドウミャク ステント ジュツゴ サイ キョウサク ヨボウ コウカ"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "東, 昭宏"}, {"creatorName": "ヒガシ, アキヒロ", "creatorNameLang": "ja-Kana"}], "nameIdentifiers": [{"nameIdentifier": "5721", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higashi, Akihiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5722", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00009214768.pdf", "filesize": [{"value": "432.9 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 432900.0, "url": {"label": "KJ00009214768.pdf", "url": "https://dmu.repo.nii.ac.jp/record/1175/files/KJ00009214768.pdf"}, "version_id": "e5ff0287-b0d6-4633-83be-c5d6992deee2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "インスリン抵抗性", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Homeostasis Model Assessment 指数", "subitem_subject_scheme": "Other"}, {"subitem_subject": "冠動脈ステント術", "subitem_subject_scheme": "Other"}, {"subitem_subject": "再狭窄", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "インスリン抵抗性改善による冠動脈ステント術後再狭窄予防効果", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "インスリン抵抗性改善による冠動脈ステント術後再狭窄予防効果"}, {"subitem_title": "Improvement of Insulin Resistance Prevents Coronary Restenosis after Percutaneous Coronary Stent Implantation", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["69"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/1175", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "1175", "relation": {}, "relation_version_is_last": true, "title": ["インスリン抵抗性改善による冠動脈ステント術後再狭窄予防効果"], "weko_shared_id": 3}