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  1. Dokkyo Journal of Medical Sciences
  2. 43(1) 2016

Effects of Neostigmine and Sugammadex on QT Interval and QT Dispersion

https://dmu.repo.nii.ac.jp/records/1290
https://dmu.repo.nii.ac.jp/records/1290
8bec574f-e9de-4a65-9788-dc729d2938cb
名前 / ファイル ライセンス アクション
KJ00010141601.pdf KJ00010141601.pdf (158.5 kB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Effects of Neostigmine and Sugammadex on QT Interval and QT Dispersion
言語 en
言語
言語 eng
キーワード
言語 en
主題 Neostigmine
キーワード
言語 en
主題 Sugammadex
キーワード
言語 en
主題 Qt Interval
キーワード
言語 en
主題 Qt Dispersion
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Effects of Neostigmine and Sugammadex on QT Interval and QT Dispersion
著者 Nagashima, Shoko

× Nagashima, Shoko

en Nagashima, Shoko

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Takasusuki, Toshifumi

× Takasusuki, Toshifumi

en Takasusuki, Toshifumi

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Yamaguchi, Shigeki

× Yamaguchi, Shigeki

en Yamaguchi, Shigeki

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Hamaguchi, Shinsuke

× Hamaguchi, Shinsuke

en Hamaguchi, Shinsuke

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著者所属(英)
en
Department Of Anesthesiology, Dokkyo Medical University, School Of Medicine
著者所属(英)
en
Department Of Anesthesiology, Dokkyo Medical University, School Of Medicine
著者所属(英)
en
Department Of Anesthesiology, Dokkyo Medical University, School Of Medicine
著者所属(英)
en
Department Of Anesthesiology, Dokkyo Medical University, School Of Medicine
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 Dispersion of QT dispersion(QTD)in 12-lead electrocardiogram is a useful index for assessment of ventricular arrhythmia risk and cardiovascular event. To determine the effects of reversal of nondepolarizing neuromuscular blockade on cardiovascular event, we evaluated the QT interval QTD after reversal of the neuromuscular blockade by neostigmine or sugammadex.After obtaining the approval of the ethics committee of Dokkyo Medical University Hospital, 40 patients with ASA physical status I or II were allocated to following two groups. Patients in the groups N(n=16)and S(n=15)received combination of neostigmine(40?μg/kg)and atropine(20?μg/kg)or sugammadex(2?mg/kg)as a reversal of neuromuscular blockade after the operation under 1% sevoflurane anesthesia, respectively. The RR interval, QT interval(QT), corrected QT interval(QTc), QT dispersion and corrected QT dispersion(QTcD)were consecutively recorded using computerized measurement before and after administration of reversal agents in both groups.RR interval in the group N significantly decreased 1-4?min after reversal of the neuromuscular blockade, but not in the group S. However, in the groups N and S, QT interval, QTc interval, QTD and QTcD were not changed after reversal of the neuromuscular blockade. Moreover, there was no significant difference between both groups in QT interval, QTc interval, QTD and QTcD during the study.Our results suggest that neither neostigmine nor sugammadex may increase the risk of ventricular arrhythmia and cardiovascular events in reversal of the neuromuscular blockade under sevoflurane anesthesia.
書誌情報 Dokkyo journal of medical sciences

巻 43, 号 1, p. 15-22, 発行日 2016-03-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
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