| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
|
|
タイトル |
Exogenous S100A4 Protein Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice by Reducing the Levels of Fibroblast Growth Factors |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題 |
S100A4 |
| キーワード |
|
|
言語 |
en |
|
主題 |
Bleomycin-treated Mice |
| キーワード |
|
|
言語 |
en |
|
主題 |
Pulmonary Fibrosis |
| キーワード |
|
|
言語 |
en |
|
主題 |
Fibroblast Growth Factors |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 雑誌書誌ID |
|
|
収録物識別子 |
AA00629581 |
| 論文名よみ |
|
|
タイトル |
Exogenous S100A4 Protein Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice by Reducing the Levels of Fibroblast Growth Factors |
| 著者 |
Watanabe, Mineaki
Hirata, Hirokuni
Tatewaki, Masamitsu
Kohyama, Kenya
Sugiyama, Kumiya
Fukushima, Yasutsugu
Ishii, Yoshiki
Fukuda, Takeshi
Arima, Masafumi
|
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Vice President Of Dokkyo Medical University:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
|
|
Department Of Respiratory Medicine And Clinical Immunology, Dokkyo Medical University Koshigaya Hospital:Department Of Pulmonary Medicine And Clinical Immunology, Dokkyo Medical University |
| 記事種別(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Background and objective:The calcium-binding protein S100A4 belongs to the S100 family and is involved in fibrotic and inflammatory processes, in which tissue remodeling, cell motility, and epithelialmesenchymal transition play major roles. Cytoplasmic S100A4 is a marker of lung fibroblasts in pulmonary fibrosis;however, the effects of exogenous S100A4 on fibrotic and inflammatory processes in pulmonary fibrosis are unclear. This study examined the effects of exogenous S100A4 protein in mice with bleomycin-induced pulmonary fibrosis.Methods:Bleomycin was administered to mice by intratracheal instillation on day 1. Intratracheal S100A4 protein was administered 4 times after bleomycin treatment. Bronchoalveolar lavage fluid was obtained and lung histological examinations were performed on day 14 after bleomycin administration. Lung tissue was homogenized on the same day to assess the mRNA expression of cytokines, fibroblast growth factors, and S100A4.Results:Unexpectedly, we observed that the administration of exogenous S100A4 protein apparently reduced lung fibrosis in bleomycin-treated mice. In addition, the levels of lymphocyte accumulation and insulin-like growth factor-1 mRNA were significantly reduced in bleomycin-treated lung by S100A4 administration.Conclusions:Exogenous S100A4 protein attenuates bleomycin-induced pulmonary fibrosis in mice by reducing lymphocyte function and the levels of fibroblast growth factors. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 43,
号 2,
p. 105-113,
発行日 2016-07-25
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03855023 |
KJ00010247939.pdf (976.0 kB)
