| Item type |
[ELS]学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-05-24 |
| タイトル |
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タイトル |
Comparison between High-dose Telmisartan and Fixed dose Combination of Telmisartan and Hydrochlorothiazide in Patients with Hypertension |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
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言語 |
en |
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主題 |
Angiotensin Ii Receptor Blocker |
| キーワード |
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言語 |
en |
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主題 |
Diuretic, Uric Acid |
| キーワード |
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言語 |
en |
|
主題 |
Fixed-dose Combination |
| キーワード |
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|
言語 |
en |
|
主題 |
Hypertension |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 雑誌書誌ID |
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|
収録物識別子 |
AA00629581 |
| 論文名よみ |
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タイトル |
Comparison between High-dose Telmisartan and Fixed dose Combination of Telmisartan and Hydrochlorothiazide in Patients with Hypertension |
| 著者 |
Murayama, Yoshiki
Ishimitsu, Toshihiko
Furuichi, Masahito
Ueno, Yasuhiko
Satonaka, Hiroshi
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| 著者所属(英) |
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|
|
en |
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Department Of Cardiology And Nephrology, Dokkyo Medical University |
| 著者所属(英) |
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en |
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Department Of Cardiology And Nephrology, Dokkyo Medical University |
| 著者所属(英) |
|
|
|
en |
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Department Of Cardiology And Nephrology, Dokkyo Medical University |
| 著者所属(英) |
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|
en |
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Department Of Cardiology And Nephrology, Dokkyo Medical University |
| 著者所属(英) |
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|
en |
|
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Department Of Cardiology And Nephrology, Dokkyo Medical University |
| 記事種別(英) |
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内容記述タイプ |
Other |
|
内容記述 |
Original |
| 抄録(英) |
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内容記述タイプ |
Other |
|
内容記述 |
We compared treatment with a high-dose angiotensin II receptor blocker(ARB)and combination of ARB with a thiazide diuretic in 17 patients with hypertension. A randomized crossover study was performed giving 80 mg telmisartan or fixed-dose combination of 40 mg telmisartan and 12.5 mg hydrochlorothiazide for 16 weeks each. Although the clinic blood pressure was comparable between the high-dose ARB period(134/81 mmHg)and the combination period(134/82 mmHg), the morning home blood pressure was lower in the combination period than in the high-dose ARB period(138/82 vs. 151/88 mmHg, p=0.026/0.013). No significant difference was observed in urinary albumin excretion, but estimated glomerular filtration rate was lower in the combination than in the high-dose ARB period(58.9 vs. 62.1 mL/min/1.73 m^2, p=0.039). Serum uric acid was higher in the combination than in the high-dose ARB period(6.7 vs. 5.9 mg/dL p=0.022). The indices of glucose metabolism, serum lipids, oxidative stress, inflammation and adipocytokine did not significantly differ between the two periods. There was no significant difference in the measurement of endothelium-dependent vasodilation between the two periods. It is suggested that the addition of thiazide diuretic to medium-dose ARB is more effective in lengthening the hypotensive effect than high-dose ARB, however, care should be taken for the elevation of serum uric acid and the decrease in renal function. |
| 書誌情報 |
Dokkyo journal of medical sciences
巻 43,
号 2,
p. 115-123,
発行日 2016-07-25
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
KJ00010247940.pdf (207.1 kB)
