ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. Dokkyo Journal of Medical Sciences
  2. 30(2) 2003

Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells

https://dmu.repo.nii.ac.jp/records/137
https://dmu.repo.nii.ac.jp/records/137
9e6d002f-8e13-4aad-ab56-6bd344562bd1
名前 / ファイル ライセンス アクション
KJ00000010468.pdf KJ00000010468.pdf (1.1 MB)
Item type [ELS]学術雑誌論文 / Journal Article(1)
公開日 2017-05-24
タイトル
タイトル Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells
言語 en
言語
言語 eng
キーワード
言語 en
主題 C-reactive protein
キーワード
言語 en
主題 serum amyloid A protein
キーワード
言語 en
主題 cytokines
キーワード
言語 en
主題 HepG2 cell
キーワード
言語 en
主題 Immunosuppressants
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
雑誌書誌ID
収録物識別子 AA00629581
論文名よみ
タイトル Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells
著者 Shimetani, Naoto

× Shimetani, Naoto

en Shimetani, Naoto

Search repository
Suzuki, Midori

× Suzuki, Midori

en Suzuki, Midori

Search repository
Shimetani, Keiko

× Shimetani, Keiko

en Shimetani, Keiko

Search repository
Nishikawa, Takashi

× Nishikawa, Takashi

en Nishikawa, Takashi

Search repository
Mori, Mikio

× Mori, Mikio

en Mori, Mikio

Search repository
著者所属(英)
en
Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine
著者所属(英)
en
Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine
著者所属(英)
en
Department of Clinical Pathology, Kitasato University School of Medicine
著者所属(英)
en
Division of Medico-chemical Analysis, Kyoritsu College of Pharmacy
著者所属(英)
en
Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine
記事種別(英)
内容記述タイプ Other
内容記述 Original
抄録(英)
内容記述タイプ Other
内容記述 C-reactive protein (CRP) and serum amyloid A protein (SAA) are acute- phase proteins produced by the liver in response to inflammatory cytokines. The concentrations of these proteins in serum vary in parallel in most pathological conditions, but sometimes vary independently. CRP and SAA were determined in HepG2 cell culture medium supplemented with five immunosuppressants (corticosteroid, gusperimus hydrochloride, cyclosporin A, mizoribine and tacrolimus hydrate), with or without interleukin-1β(IL-1β) and interleukin-6 (IL-6). We also examined the effects of the immunosuppressants on the production of cytokines and changes in CRP and SAA production in HepG2 cells stimulated with the culture fluid from lipopolysaccharide (LPS) - treated monocytes. In HepG2 cells, production of CRP and SAA was greatly affected by IL-6 and IL-β, respectively. Prednisolone (PSL) suppressed CRP production, while it enhanced SAA production. The other four immunosuppressants did not affect CRP production, but inhibited SAA production. PSL significantly inhibited cytokine production in monocytes, while the other immunosuppressants enhanced it. In HepG2 cells incubated with the culture fluid from LPS-stimulated monocytes, CRP production was suppressed, while SAA production was enhanced. PSL suppressed CRP production in HepG2 cells by inhibiting IL-6 production in monocytes, whereas PSL increased SAA production through a direct action on the hepatoma cells. In contrast, the other immunosuppressive agents enhanced IL-β production in monocytes. The agents induced SAA production in the HepG2 cells but did not affect CRP production.
書誌情報 Dokkyo journal of medical sciences

巻 30, 号 2, p. 131-139, 発行日 2003-07-25
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
戻る
0
views
See details
Views

Versions

Ver.1 2023-06-20 16:22:59.593217
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3