{"_buckets": {"deposit": "dcd95af7-072b-4d9a-98af-fed6db63590f"}, "_deposit": {"created_by": 3, "id": "137", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "137"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00000137", "sets": ["26"]}, "author_link": ["431", "432", "428", "430", "429"], "item_2_biblio_info_12": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2003-07-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "139", "bibliographicPageStart": "131", "bibliographicVolumeNumber": "30", "bibliographic_titles": [{"bibliographic_title": "Dokkyo journal of medical sciences"}]}]}, "item_2_description_11": {"attribute_name": "抄録(英)", "attribute_value_mlt": [{"subitem_description": "C-reactive protein (CRP) and serum amyloid A protein (SAA) are acute- phase proteins produced by the liver in response to inflammatory cytokines. The concentrations of these proteins in serum vary in parallel in most pathological conditions, but sometimes vary independently. CRP and SAA were determined in HepG2 cell culture medium supplemented with five immunosuppressants (corticosteroid, gusperimus hydrochloride, cyclosporin A, mizoribine and tacrolimus hydrate), with or without interleukin-1β(IL-1β) and interleukin-6 (IL-6). We also examined the effects of the immunosuppressants on the production of cytokines and changes in CRP and SAA production in HepG2 cells stimulated with the culture fluid from lipopolysaccharide (LPS) - treated monocytes. In HepG2 cells, production of CRP and SAA was greatly affected by IL-6 and IL-β, respectively. Prednisolone (PSL) suppressed CRP production, while it enhanced SAA production. The other four immunosuppressants did not affect CRP production, but inhibited SAA production. PSL significantly inhibited cytokine production in monocytes, while the other immunosuppressants enhanced it. In HepG2 cells incubated with the culture fluid from LPS-stimulated monocytes, CRP production was suppressed, while SAA production was enhanced. PSL suppressed CRP production in HepG2 cells by inhibiting IL-6 production in monocytes, whereas PSL increased SAA production through a direct action on the hepatoma cells. In contrast, the other immunosuppressive agents enhanced IL-β production in monocytes. The agents induced SAA production in the HepG2 cells but did not affect CRP production.", "subitem_description_type": "Other"}]}, "item_2_description_15": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_description": "4", "subitem_description_type": "Other"}]}, "item_2_description_16": {"attribute_name": "アクセション番号", "attribute_value_mlt": [{"subitem_description": "KJ00000010468", "subitem_description_type": "Other"}]}, "item_2_description_9": {"attribute_name": "記事種別(英)", "attribute_value_mlt": [{"subitem_description": "Original", "subitem_description_type": "Other"}]}, "item_2_source_id_1": {"attribute_name": "雑誌書誌ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_19": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_7": {"attribute_name": "著者所属(英)", "attribute_value_mlt": [{"subitem_text_language": "en", "subitem_text_value": "Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Clinical Pathology, Kitasato University School of Medicine"}, {"subitem_text_language": "en", "subitem_text_value": "Division of Medico-chemical Analysis, Kyoritsu College of Pharmacy"}, {"subitem_text_language": "en", "subitem_text_value": "Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine"}]}, "item_2_title_3": {"attribute_name": "論文名よみ", "attribute_value_mlt": [{"subitem_title": "Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimetani, Naoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "428", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suzuki, Midori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "429", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimetani, Keiko", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "430", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishikawa, Takashi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "431", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mori, Mikio", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "432", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-05-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "KJ00000010468.pdf", "filesize": [{"value": "1.1 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 1100000.0, "url": {"label": "KJ00000010468.pdf", "url": "https://dmu.repo.nii.ac.jp/record/137/files/KJ00000010468.pdf"}, "version_id": "7929f0b8-baae-4875-9f9f-c7980ed64f80"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "C-reactive protein", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "serum amyloid A protein", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cytokines", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HepG2 cell", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Immunosuppressants", "subitem_subject_language": "en", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells", "subitem_title_language": "en"}]}, "item_type_id": "2", "owner": "3", "path": ["26"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/137", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-24"}, "publish_date": "2017-05-24", "publish_status": "0", "recid": "137", "relation": {}, "relation_version_is_last": true, "title": ["Effects of Cytokines and Immunosuppressants on the Production of Serum Amyloid A Protein and C-reactive Protein in HepG2 Cells"], "weko_shared_id": 3}