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Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers
https://dmu.repo.nii.ac.jp/records/1473
https://dmu.repo.nii.ac.jp/records/14736217d9c3-6d23-43c6-9def-090e9c724f1d
名前 / ファイル | ライセンス | アクション |
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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タイトル | ||||||
タイトル | Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | tadalafil | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | benign prostatic hyperplasia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lower urinary tract symptoms | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | refractory to alpha-1 adrenoceptor blockers | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yagi, Hiroshi
× Yagi, Hiroshi× Arai, Gaku× Soh, Shigehiro× Okada, Hiroshi |
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著者所属 | ||||||
Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||
著者所属 | ||||||
Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||
著者所属 | ||||||
Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||
著者所属 | ||||||
Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||
書誌情報 |
Dokkyo Journal of Medical Sciences 巻 44, 号 1, p. 17-23, 発行日 2017-03-25 |
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要旨 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Introduction:To evaluate the efficacy and safety of once daily phosphodiesterase type 5 inhibitor(PDE5i) tadalafil as an add-on treatment for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia(BPH/LUTS)refractory to an alpha 1-blocker(a1-blocker). Materials and Methods:This study enrolled men aged >50 years with BPH/LUTS and erectile dysfunction(ED) that were refractory to >3 months of a1-blocker. We defined “refractory” as an international prostate symptoms score (IPSS) of >8 and a maximum flow rate (Qmax) <15 despite in no space take of an a1-blocker. Patients with contraindications to phosphodiesterase-5 inhibitors;those with symptoms of other diseases that were difficult to differentiate from BPH/LUTS;and those with postvoid residual of >100 ml were excluded. Eligible patients received added-on treatment with tadalafil 5 mg/day for 12 weeks. Results:Tadalafil add-on treatment significantly improved the IPSS parameters in terms of total score(P<0.001), subscore for storage(P=0.001), subscore for voiding(P<0.001), and quality of life(P=0.002). The 3-day frequency volume chart showed significant improvements in mean number of daily nocturnal micturations(P=0.002), nocturnal polyuria index(P=0.001), and hours of undisturbed sleep(P=0.006). Five patients dropped out because of an adverse event:two with a headache, two with dizziness and one with dyspepsia. There were no serious adverse events. Conclusion:Tadalafil add-on treatment was effective for patients with BPH/LUTS and ED that were resistant to a1-blockers. |
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記事種別 | ||||||
Original | ||||||
出版者 | ||||||
出版者 | 獨協医学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855023 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00629581 | |||||
表示順 | ||||||
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