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  1. Dokkyo Journal of Medical Sciences
  2. 44(1) 2017

Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers

https://dmu.repo.nii.ac.jp/records/1473
https://dmu.repo.nii.ac.jp/records/1473
6217d9c3-6d23-43c6-9def-090e9c724f1d
名前 / ファイル ライセンス アクション
DJMS-44-1-4.pdf DJMS-44-1-Yagi2-本文 (86.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers
言語
言語 eng
キーワード
主題Scheme Other
主題 tadalafil
キーワード
主題Scheme Other
主題 benign prostatic hyperplasia
キーワード
主題Scheme Other
主題 lower urinary tract symptoms
キーワード
主題Scheme Other
主題 refractory to alpha-1 adrenoceptor blockers
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Yagi, Hiroshi

× Yagi, Hiroshi

en Yagi, Hiroshi

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Arai, Gaku

× Arai, Gaku

en Arai, Gaku

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Soh, Shigehiro

× Soh, Shigehiro

en Soh, Shigehiro

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Okada, Hiroshi

× Okada, Hiroshi

en Okada, Hiroshi

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著者所属
値 Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
著者所属
値 Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
著者所属
値 Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
著者所属
値 Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
書誌情報 Dokkyo Journal of Medical Sciences

巻 44, 号 1, p. 17-23, 発行日 2017-03-25
要旨
内容記述タイプ Other
内容記述 Introduction:To evaluate the efficacy and safety of once daily phosphodiesterase type 5 inhibitor(PDE5i) tadalafil as an add-on treatment for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia(BPH/LUTS)refractory to an alpha 1-blocker(a1-blocker).

Materials and Methods:This study enrolled men aged >50 years with BPH/LUTS and erectile dysfunction(ED) that were refractory to >3 months of a1-blocker. We defined “refractory” as an international prostate symptoms score (IPSS) of >8 and a maximum flow rate (Qmax) <15 despite in no space take of an a1-blocker. Patients with contraindications to phosphodiesterase-5 inhibitors;those with symptoms of other diseases that were difficult to differentiate from BPH/LUTS;and those with postvoid residual of >100 ml were excluded. Eligible patients received added-on treatment with tadalafil 5 mg/day for 12 weeks.

Results:Tadalafil add-on treatment significantly improved the IPSS parameters in terms of total score(P<0.001), subscore for storage(P=0.001), subscore for voiding(P<0.001), and quality of life(P=0.002). The 3-day frequency volume chart showed significant improvements in mean number of daily nocturnal micturations(P=0.002), nocturnal polyuria index(P=0.001), and hours of undisturbed sleep(P=0.006). Five patients dropped out because of an adverse event:two with a headache, two with dizziness and one with dyspepsia. There were no serious adverse events.

Conclusion:Tadalafil add-on treatment was effective for patients with BPH/LUTS and ED that were resistant to a1-blockers.
記事種別
値 Original
出版者
出版者 獨協医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00629581
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