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Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers
https://dmu.repo.nii.ac.jp/records/1473
https://dmu.repo.nii.ac.jp/records/14736217d9c3-6d23-43c6-9def-090e9c724f1d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
DJMS-44-1-Yagi2-本文 (86.1 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| タイトル | ||||||||||||||
| タイトル | Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | tadalafil | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | benign prostatic hyperplasia | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | lower urinary tract symptoms | |||||||||||||
| キーワード | ||||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | refractory to alpha-1 adrenoceptor blockers | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Yagi, Hiroshi
× Yagi, Hiroshi
× Arai, Gaku
× Soh, Shigehiro
× Okada, Hiroshi
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| 著者所属 | ||||||||||||||
| Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||||||||||
| 著者所属 | ||||||||||||||
| Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan | ||||||||||||||
| 書誌情報 |
Dokkyo Journal of Medical Sciences 巻 44, 号 1, p. 17-23, 発行日 2017-03-25 |
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| 要旨 | ||||||||||||||
| 内容記述タイプ | Other | |||||||||||||
| 内容記述 | Introduction：To evaluate the efficacy and safety of once daily phosphodiesterase type 5 inhibitor(PDE5i) tadalafil as an add-on treatment for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia（BPH/LUTS）refractory to an alpha 1-blocker（a1-blocker）. Materials and Methods：This study enrolled men aged ＞50 years with BPH/LUTS and erectile dysfunction(ED) that were refractory to ＞3 months of a1-blocker. We defined “refractory” as an international prostate symptoms score (IPSS) of ＞8 and a maximum flow rate (Qmax) ＜15 despite in no space take of an a1-blocker. Patients with contraindications to phosphodiesterase-5 inhibitors；those with symptoms of other diseases that were difficult to differentiate from BPH/LUTS；and those with postvoid residual of ＞100 ml were excluded. Eligible patients received added-on treatment with tadalafil 5 mg/day for 12 weeks. Results：Tadalafil add-on treatment significantly improved the IPSS parameters in terms of total score（P＜0.001）, subscore for storage（P＝0.001）, subscore for voiding（P＜0.001）, and quality of life（P＝0.002）. The 3-day frequency volume chart showed significant improvements in mean number of daily nocturnal micturations（P＝0.002）, nocturnal polyuria index（P＝0.001）, and hours of undisturbed sleep（P＝0.006）. Five patients dropped out because of an adverse event：two with a headache, two with dizziness and one with dyspepsia. There were no serious adverse events. Conclusion：Tadalafil add-on treatment was effective for patients with BPH/LUTS and ED that were resistant to a1-blockers. |
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| 記事種別 | ||||||||||||||
| Original | ||||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | 獨協医学会 | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 03855023 | |||||||||||||
| 書誌レコードID | ||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||
| 収録物識別子 | AA00629581 | |||||||||||||
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