{"_buckets": {"deposit": "85b3979f-cb68-48ec-8092-08599e525d15"}, "_deposit": {"created_by": 14, "id": "1473", "owners": [14], "pid": {"revision_id": 0, "type": "depid", "value": "1473"}, "status": "published"}, "_oai": {"id": "oai:dmu.repo.nii.ac.jp:00001473", "sets": ["86"]}, "author_link": ["4072", "5808", "4065", "4073"], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageEnd": "23", "bibliographicPageStart": "17", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Dokkyo Journal of Medical Sciences"}]}]}, "item_10001_description_34": {"attribute_name": "要旨", "attribute_value_mlt": [{"subitem_description": "Introduction：To evaluate the efficacy and safety of once daily phosphodiesterase type 5 inhibitor(PDE5i) tadalafil as an add-on treatment for men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia（BPH/LUTS）refractory to an alpha 1-blocker（a1-blocker）. \n\nMaterials and Methods：This study enrolled men aged ＞50 years with BPH/LUTS and erectile dysfunction(ED) that were refractory to ＞3 months of a1-blocker. We defined “refractory” as an international prostate symptoms score (IPSS) of ＞8 and a maximum flow rate (Qmax) ＜15 despite in no space take of an a1-blocker. Patients with contraindications to phosphodiesterase-5 inhibitors；those with symptoms of other diseases that were difficult to differentiate from BPH/LUTS；and those with postvoid residual of ＞100 ml were excluded. Eligible patients received added-on treatment with tadalafil 5 mg/day for 12 weeks. \n\nResults：Tadalafil add-on treatment significantly improved the IPSS parameters in terms of total score（P＜0.001）, subscore for storage（P＝0.001）, subscore for voiding（P＜0.001）, and quality of life（P＝0.002）. The 3-day frequency volume chart showed significant improvements in mean number of daily nocturnal micturations（P＝0.002）, nocturnal polyuria index（P＝0.001）, and hours of undisturbed sleep（P＝0.006）. Five patients dropped out because of an adverse event：two with a headache, two with dizziness and one with dyspepsia. There were no serious adverse events. \n\nConclusion：Tadalafil add-on treatment was effective for patients with BPH/LUTS and ED that were resistant to a1-blockers.", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "獨協医学会"}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00629581", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855023", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_text_24": {"attribute_name": "著者所属", "attribute_value_mlt": [{"subitem_text_value": "Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"}, {"subitem_text_value": "Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"}, {"subitem_text_value": "Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"}, {"subitem_text_value": "Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan"}]}, "item_10001_text_28": {"attribute_name": "表示順", "attribute_value_mlt": [{"subitem_text_value": "４"}]}, "item_10001_text_33": {"attribute_name": "記事種別", "attribute_value_mlt": [{"subitem_text_value": "Original"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Yagi, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4065", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arai, Gaku", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4072", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Soh, Shigehiro", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "5808", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okada, Hiroshi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "4073", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2018-07-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "DJMS-44-1-4.pdf", "filesize": [{"value": "86.1 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 86100.0, "url": {"label": "DJMS-44-1-Yagi2-本文", "url": "https://dmu.repo.nii.ac.jp/record/1473/files/DJMS-44-1-4.pdf"}, "version_id": "c1bb3320-afa6-4f15-b74e-d25514716e16"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "tadalafil", "subitem_subject_scheme": "Other"}, {"subitem_subject": "benign prostatic hyperplasia", "subitem_subject_scheme": "Other"}, {"subitem_subject": "lower urinary tract symptoms", "subitem_subject_scheme": "Other"}, {"subitem_subject": "refractory to alpha-1 adrenoceptor blockers", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers"}]}, "item_type_id": "10001", "owner": "14", "path": ["86"], "permalink_uri": "https://dmu.repo.nii.ac.jp/records/1473", "pubdate": {"attribute_name": "公開日", "attribute_value": "2018-07-09"}, "publish_date": "2018-07-09", "publish_status": "0", "recid": "1473", "relation": {}, "relation_version_is_last": true, "title": ["Efficacy of Tadalafil Add-on Treatment for Men with Lower Urinary Tract Symptoms Refractory to Alpha-1 Adrenoceptor Blockers"], "weko_shared_id": -1}