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  1. Dokkyo Journal of Medical Sciences
  2. 45(1) 2018

Physiological Role of L-type Amino Acid Transporter 1 in Two Lines of Cultured Choriocarcinoma Cells, JAR and JEG-3

https://dmu.repo.nii.ac.jp/records/1502
https://dmu.repo.nii.ac.jp/records/1502
be8a5580-9a76-463c-a2a1-4bb6c69f142f
名前 / ファイル ライセンス アクション
DJMS-45-1-4.pdf DJMS-45-1-Tochigi-本文 (330.1 kB)
Item type 学術雑誌論文 / Journal Article(1)
タイトル
タイトル Physiological Role of L-type Amino Acid Transporter 1 in Two Lines of Cultured Choriocarcinoma Cells, JAR and JEG-3
言語
言語 eng
キーワード
主題Scheme Other
主題 cancer
キーワード
主題Scheme Other
主題 transporter
キーワード
主題Scheme Other
主題 amino acids
キーワード
主題Scheme Other
主題 leucine
キーワード
主題Scheme Other
主題 choriocarcinoma
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Tochigi, Tatsuko

× Tochigi, Tatsuko

en Tochigi, Tatsuko

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Morita, Asuka

× Morita, Asuka

en Morita, Asuka

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Ouchi, Motoshi

× Ouchi, Motoshi

en Ouchi, Motoshi

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Hayashi, Keitaro

× Hayashi, Keitaro

en Hayashi, Keitaro

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Fujita, Tomoe

× Fujita, Tomoe

en Fujita, Tomoe

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Fukazawa, Ichio

× Fukazawa, Ichio

en Fukazawa, Ichio

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Anzai, Naohiko

× Anzai, Naohiko

en Anzai, Naohiko

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著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan:Department of Gynecology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
値 Department of Gynecology, Dokkyo Medical University School of Medicine, Tochigi, Japan
著者所属
値 Department of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Tochigi, Japan:Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan
書誌情報 Dokkyo Journal of Medical Sciences

巻 45, 号 1, p. 17-26, 発行日 2018-03-25
要旨
内容記述タイプ Other
内容記述 In cells that proliferate abundantly, such as cancer cells, the expressions of many nutrient transporters increase in order to drive the uptake of required nutrients. The system L transporters are the main sodium-independent neutral amino acid transporters. They have four isoforms:L-type amino acid transporter (LAT) 1, 2, 3, and 4. The expression of LAT1 has been reported in lines of cultured choriocarcinoma cells. However, the role of LAT1 in choriocarcinomas has not been adequately clarified. This study examined the role of LAT1 in these cell lines JAR and JEG-3.
Based on an examination of mRNA and protein expression, it was determined that both JAR and JEG-3 cells express LAT1. The uptake of leucine, a substrate of LATs, by JAR and JEG-3 cells showed that there are sodium-independent leucine transport. To examine whether leucine transport is mediated by LAT1, a leucine uptake was examined with loading of JPH203, a LAT1 specific inhibitor, and transport inhibition was clearly seen. Cell counts were measured to examine whether cell proliferation was decreased by JPH203 treatment. Inhibition of JEG-3 cell proliferation was seen on day 4 of the treatment. No inhibition of JAR cell proliferation was seen by low concentrations of JPH203, however inhibition was seen on a higher concentration of JPH203. JPH203 decreased cell activityconcentration-dependently in JEG-3 cells. JAR cell, however, showed an increased activity following JPH203 treatment at low concentrations. Thus, the study found that LAT1-mediated amino acid transport occurs in these two different lines of cultured choriocarcinoma cells. Moreover, it showed that the two types of cells responded differently with respect to inhibition of cell proliferation and changes in cell activity as a result of inhibition of LAT1-mediated amino acid transport. The results showed that LAT1-mediated amino acid transport in choriocarcinoma is complex and has a variety of functions.
記事種別
値 Original
出版者
出版者 獨協医学会
ISSN
収録物識別子タイプ ISSN
収録物識別子 03855023
書誌レコードID
収録物識別子タイプ NCID
収録物識別子 AA00629581
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