| Item type |
学術雑誌論文 / Journal Article(1) |
| タイトル |
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|
タイトル |
Comparisons of Increasing Calcium Channel Blocker dose and Adding Thiazide Diuretic in Hypertensive Patients Given Medium-dose Angiotensin II Receptor Blocker and Amlodipine |
| 言語 |
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言語 |
eng |
| キーワード |
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主題Scheme |
Other |
|
主題 |
angiotensin II receptor blocker |
| キーワード |
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主題Scheme |
Other |
|
主題 |
calcium channel blocker |
| キーワード |
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主題Scheme |
Other |
|
主題 |
diuretic |
| キーワード |
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主題Scheme |
Other |
|
主題 |
uric acid |
| キーワード |
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主題Scheme |
Other |
|
主題 |
fixed-dose combination |
| キーワード |
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主題Scheme |
Other |
|
主題 |
hypertension |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Takehiro, Ohira
Toshihiko, Ishimitsu
Akihisa, Yabe
Masahito, Furuichi
Yasuhiko, Ueno
Shou, Onoda
Akihiko, Nagase
Yoshiki, Murayama
Hiroshi, Satonaka
Akihiro, Tojo
|
| 著者所属 |
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|
値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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|
値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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|
値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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|
値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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|
値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 著者所属 |
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|
値 |
Department of Cardiology and Nephrology, Dokkyo Medical University, Mibu, Tochigi, Japan |
| 書誌情報 |
Dokkyo Journal of Medical Sciences
巻 44,
号 3,
p. 209-216,
発行日 2017-10-25
|
| 要旨 |
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内容記述タイプ |
Other |
|
内容記述 |
We compared the efficacies of 2 prescriptions, one of a medium-dose angiotensin II receptor blocker （ARB） with high-dose of calcium channel blocker （CCB） and another of medium-dose of ARB with medium-dose of CCB and a thiazide diuretic in 22 hypertensive patients who did not achieve the target blood pressure level with the combination of medium-dose of ARB and medium-dose of CCB. A randomized crossover study was performed giving a fixed combination of 100 mg irbesartan with 10 mg amlodipine or a fixed-dose combination of 100 mg irbesartan with 5 mg amlodipine added by 1 mg trichlormethiazide for 12-16 weeks each. The blood pressure measured in hospital was comparable between the high-dose CCB period （130/77 mmHg） and the thiazide period （130/79 mmHg）. The morning and the evening blood pressures measured at home were also comparable in the high-dose of CCB and the thiazide periods, while the evening heart rate was higher in the thiazide period than in the high-dose CCB period. As for the laboratory data, hemoglobin A1c （＋0.2％, p＝0.013）, serum nonHDL cholesterol （＋12 mg/dL, p＝0.047） and serum uric acid （＋0.8 mg/dL, p＝0.001） were significantly higher in the thiazide period than in the high-dose CCB period. On the other hand, urinary albumin excretion （－28.8％，p＝0.026） and estimated glomerular filtration rate （－5.8％，p＝0.012） were significantly lower in the thiazide period than in the high-dose CCB period. In the combination drug therapy of hypertension, the increase of CCB dose is preferable in preserving renal function and in avoiding adverse effects on metabolisms of glucose, lipid and uric acid. |
| 記事種別 |
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|
値 |
Original |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03855023 |
| 書誌レコードID |
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収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00629581 |
| 表示順 |
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|
値 |
3 |
DJMS-44-3-Ohira-本文 (702.0 kB)
